Objectives This study determined whether online continuing medical education (CME) could improve the knowledge of oncologists (oncs) and obstetricians/gynaecologists (obs/gyns) regarding the rationale and evidence for immunotherapy paradigms in advanced endometrial cancer.

Methods A 30-minute online video lecture was launched for physicians outside the USA August 2020 with data collected to November 2020. Educational effect assessed with repeated-pairs pre-/post-activity- individual participants serving as own control. 3 multiple-choice, knowledge questions and 1 self-efficacy, 5-point Likert scale confidence question were analyzed. Chi-squared test assessed pre- to post-activity change (5% significance level, P <.05). Magnitude of change in total number of correct responses overall, and for each question, determined with Cramer’s V (<.06=Modest, 0.06–0.15=Noticeable, 0.16–0.26=Considerable, >.26=Extensive).

Results 142 obs/gyns and 60 oncs completed pre- and post-activity questions. Positive educational effect was observed for obs/gyns (noticeable effect, V=.092, P<.01; average% of correct responses increasing from 33 to 42%) and oncs (noticeable effect, V=.150, P=.0043; average% of correct responses increasing from 47 to 62%). Increases in correct responses post-activity seen for questions on response to 2nd line chemotherapy (% relative improvement, obs/gyn: 23%, oncs 22%), rationale for immunotherapy (obs/gyns: 24%, oncs: 72%), data for the dostarlimab GARNET trial (obs/gyns: 36%, oncs: 21%). Confidence in knowledge of the evidence for immunotherapy strategies increased post-activity (total average confidence shift: 27% obs/gyns and 40% oncs). Overall, 22% of learners’ responses were improved and 39% of learners’ responses were reinforced.

Conclusions This online CME activity resulted in a positive educational impact for both clinical specialties. However, education gaps remained evident post-activity.