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43 Factors influencing patient reported outcomes in women with endometrial cancer: validation of the slovenian EORTC QLQ-EN24 instrument
  1. E Gjuras1,
  2. D Gašpar1,
  3. M Sobočan1,2 and
  4. J Knez1,2
  1. 1University of Maribor, Faculty of Medicine, Maribor, Slovenia
  2. 2University Medical Centre Maribor, Division for Gynaecology and Perinatology, Maribor, Slovenia


Introduction/Background*Improved survival in patients with endometrial cancer has led to increased awareness about the quality of life (QoL) after treatment. QoL refers to a multidimensional assessment that includes physical, emotional, and psychological domains. An important part of QoL are patient reported outcomes (PROs). This study assessed PROs in women with endometrial cancer and assessed the impact of therapy on PROs.

Methodology Women with endometrial cancer treated at the University Medical Centre Maribor between January 2016 - December 2019 were invited to participate in the study in April 2021 by post. Under supervision of EORTC, the authors translated the disease specific EORTC QLQ-EN24 questionnaire to the Slovene language in accordance with EORTC guidelines. Demographic and clinical treatment data was evaluated and correlated with the QLQ-EN24 dimensions. Correlations were performed using the Spearman rank test, continuous data was compared using the Mann-Whitney U test. Data were evaluated using the SPSS for Mac version 23.0

Result(s)*Seventy-nine women participated in this study (response rate 51%). Cronbach’s alpha for items in the Slovenian version of the EORTC QLQ-EN24 scale was 0.72. Median age of women was 64 years (36-85). Follow up time was 4 years (2-5). Sexual activity in the last 4 weeks prior to filling out the questionnaire was reported in 26 women (32%). Median body mass index (BMI) was 31 (19-52). BMI was correlated with worse reported outcomes in lymphoedema (rs=-.246, p<.045) and urological symptoms (rs=-.246, p<.044). Age was correlated only with items regarding poor body image (rs=-.350, p<.002), sexual interest (rs=-.408, p<.001) and sexual activity (rs=-.506, p<.001). No other symptoms assessed were correlated with age. No patient recorded symptoms were correlated with surgery type (minimally invasive or open surgery) nor with lymph node treatment.

Conclusion*Our pilot study using a Slovenian version of the EORTC QLQ-EN24 showed adequate internal consistency. An initial analysis of the treatment mode did not impact patient reported health symptoms. There is a need for further understanding and support to women to prevent health symptoms post treatment and improve PROs.

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