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846 Cancer-induced accelerated immunoaging in women suffering from ovarian cancer
  1. S Marcoux,
  2. T Kientega,
  3. GB Cardin,
  4. MF Raynault,
  5. AM Mes-Masson,
  6. D Provencher and
  7. F Rodier
  1. Université de Montréal Faculty of Medicine, Médecine, Montreal, Canada


Introduction/Background*Advanced age is a poor prognostic risk factor for most epithelial ovarian cancers. Individuals suffering from socioeconomic deprivation have a lower life expectation and a higher risk for most chronic diseases, including cancer. There is also mounting evidence that undergoing cancer treatments is associated with accelerated cellular aging. Hypothesis: extensive accelerated aging caused by 1) socioeconomic status, 2) cancer itself and 3) cancer therapy is associated with worse prognosis in women suffering from primary ovarian cancer.

Methodology We retrospectively analyzed the immunological age of 488 women diagnosed and treated for a primary ovarian serous carcinoma in specialized care center in Montréal (Québec, CANADA) from 1999 to 2019. Neighborhood socioeconomic status at diagnosis for each woman was inferred from their postal code area linked to socioeconomic indicators derived from the Canadian census data. Immunological age was measured using a forensic medicine validated blood biomarker (TRECs – T-cell receptor excision circles). Blood sample were available before treatments (n = 196), after treatments (n = 270), or paired before and after treatments (n = 22). Time was calculated from diagnosis date to death, relapse or study censoring (last relapse-free follow-up date).

Result(s)*In our study sample, neighborhood socioeconomic status at diagnosis did not affect overall survival. We observed that accelerated immunological aging was occurring before treatment initiation (n = 218, p < 0.0001). Treatment itself was not associated with a significant additional accelerated immunoaging (n = 22). Neither higher FIGO stage at diagnosis nor neighborhood socioeconomic status at diagnosis were associated with a higher disparity between chronological and immunological age.

Conclusion*Our preliminary study results support that either cancer itself causes a significant immunological age shift in women suffering from a primary ovarian serous carcinoma, or that women suffering from accelerated aging are more prone to develop cancer. Although statistical underpower and a biased sample effect cannot be excluded, the socioeconomic status does not seem to influence accelerated immunoaging nor overall survival.

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