Article Text
PDF
Abstract
Objective The aim of this study was to compare the survival outcomes of adenosquamous carcinoma (ASC) and adenocarcinoma (AC) of the cervix.
Methods We searched PubMed and Embase for observational studies that compared the outcomes of 2 histologic subtypes. Hazards ratios (HRs) with 95% confidence intervals (CIs) were calculated with a fixed effects model.
Results A total of 17 studies were included in the analyses. Patients with ASC were associated significantly with poorer overall survival (death HR, 1.27; 95% CI, 1.12–1.43; I2 = 0%) and recurrence-free survival (recurrence HR, 1.43; 95% CI, 1.05–1.95; I2 = 19.4%) than those with AC. For clinical stages I and II in particular, ASC predicted significantly poorer outcomes compared with AC (death HR, 1.41; 95% CI, 1.17–1.70; I2 = 0%).
Conclusions This meta-analysis suggests that ASC may have poorer outcomes compared with AC of the cervix.
- Cervical cancer
- Adenosquamous carcinoma
- Adenocarcinoma
- Survival
- Prognosis
- Meta-analysis
Statistics from Altmetric.com
Footnotes
This work was supported by Research Resettlement Fund for the new faculty of Seoul National University.
The authors declare no conflicts of interest.
Request Permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.