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Surgery Versus Radiation Therapy for Stage IB2 Cervical Carcinoma: A Population-Based Analysis
  1. Bunja Rungruang, MD*,
  2. Madeleine Courtney-Brooks, MD*,
  3. Sushil Beriwal, MD,
  4. Kristin K. Zorn, MD*,
  5. Scott D. Richard, MD*,
  6. Alexander B. Olawaiye, MD*,
  7. Thomas C. Krivak, MD* and
  8. Paniti Sukumvanich, MD*
  1. * Division of Gynecologic Oncology, Department of Obstetrics, Gynecology,and Reproductive Sciences, and
  2. Department of Radiation Oncology, Magee-Women’s Hospital of UPMC, Pittsburgh, PA.
  1. Address correspondence and reprint requests to Paniti Sukumvanich, MD, Magee-Women’s Hospital of UPMC, Division of Gynecologic Oncology, 300 Halket At, Suite 2130, Pittsburgh, PA. E-mail: sukupx{at}mail.magee.edu.

Abstract

Objective The objective of the study was to examine outcomes in stage IB2 cervical cancer patients undergoing primary surgery versus radiation.

Methods Stage IB2 cervical cancer patients were identified from the Surveillance, Epidemiology and End Results Public-Use Database from 2000 to 2006. Patients were divided into those receiving radiation (radiation first) or surgery (surgery first) as initial treatment. Overall survival was calculated by Kaplan-Meier method and compared using log-rank test.

Results In total, 770 patients were identified with stage IB2 cervical cancer; 369 received radiation, and 401 received surgery initially. The radiation-first group had larger mean tumor size than the surgery-first group (6.0 vs 5.5 cm, respectively; P < 0.0001). The overall survival was longer in the surgery-first group compared with the radiation-first group (72.0 vs 61.4 months, respectively; P < 0.0001).

Conclusions Patients undergoing surgery as initial treatment for stage IB2 cervical cancer appear to have improved outcomes in the current era of chemoradiation; however, given the lack of chemotherapy information, a randomized trial will be necessary to see if these results remain valid.

  • Cervical cancer
  • Chemoradiation
  • Radiation
  • Radical hysterectomy

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Footnotes

  • The authors have no conflicts of interest to declare.

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