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Major prognostic factors in ovarian carcinomas
  1. H. Haapasalo*,
  2. Y. Collan and
  3. N. B. Atkin
  1. * Departments of Pathology, Mikkeli Central Hospital, Mikkeli and University of Kuopio, Kuopio, Finland;
  2. Department of Pathology, University of Turku, Turku, Finland
  3. Department of Cancer Research, Mount Vernon Hospital, Northwood, Middlesex, England
  1. Address for correspondence: Dr H. Haapasalo, Department of Pathology, University Hospital of Tampere, SF-33520 Tampere, Finland.


Prognostic variables predictive of survival in ovarian carcinoma were studied in 91 patients with stage I–IV disease. Univariate analysis showed that clinical stage (FIGO), presence of ascites, age of patient, histologic type and grade, cellular DNA content, morphometric grade, mitotic activity index, and volume corrected mitotic index (M/V index) were prognostic. Multivariate analysis using a Cox model showed that the stage (best predictor in total material), the M/V index (best predictor in stage I tumors), the DNA content (best predictor in advanced stages), and ascites were independently prognostic. Morphometry and/or DNA cytometry should be standard in the histo-pathological evaluation of ovarian carcinomas.

  • malignancy grading
  • mitotic index
  • morphometry
  • ovary carcinoma
  • prognosis
  • static DNA-cytometry.

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