Introduction/Background*The surgical management of advanced epithelial ovarian cancer (AEOC) is controversial in fragile subjects like elderly patients. The aim of this study was to report the global survival of primary and interval debulking surgery (PDS/IDS) over 65 years and to compare the outcomes with younger patients.

Methodology Between 2005 and 2016, 145 patients with ovarian cancer in FIGO stages IIIC or IV and PDS or IDS were included. We compared patient characteristics, type of surgery, major postoperative complications, hospital length of stay, disease free survival (DFS) and ovarall survival (OS) for patients under and over 65 years.

Result(s)*93 patients were up to 65 years and 60 patients were over. There were no difference between the two groups for performance status, CA 125, tumors hystotypes and FIGO stage. Charlson comorbidity index and tumor grade were higher among aged patients. The proportion of PDS and the surgical complexity score did not show statiscally signficative differences, as well as the rate of major postoperative complications or length of stay.

Patients over 65 years had optimal cytorreduction in 78.3%, the progression free survival was 19.1months and overall survival was the 48.7 months compared with patients up to 65 years, which had 87.1% of optimal debulking surgery, 24.6 months of DFS and 52.7 months. None of these outcomes revealed any statistical significant difference between groups.

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Abstract 49 Figure 1

Kaplan Meier curves. Overall survival in advance ovarian cancer after bebulking surgery

Conclusion*The survival outcomes in elderly ovarian cancer patients are the same as younger patients. The age should not be the main factor to decide the upfront treatment of AEOC.