Clinical Trial

Olaparib beyond progression compared with platinum chemotherapy after secondary cytoreductive surgery in patients with recurrent ovarian cancer: phase III randomized, open-label MITO 35b study, a project of the MITO-MANGO groups

Clorinda Schettino, Lucia Musacchio, Michele Bartoletti, Paolo Chiodini, Laura Arenare, Gustavo Baldassarre, Daniela Califano, Ettore Capoluongo, Maria Paola Costi, Maurizio D'Incalci, Sergio Marchini, Delia Mezzanzanica, Nicola Normanno, Stefania Scala, Stefano Greggi, Francesco Perrone, Sandro Pignata

10.1136/ijgc-2022-003435

March 22, 2022

Sentinel lymph node mapping versus sentinel lymph node mapping with systematic lymphadenectomy in endometrial cancer: an open-label, non-inferiority, randomized trial (ALICE trial)

Glauco Baiocchi, Carlos Eduardo Mattos Cunha Andrade, Reitan Ribeiro, Renato Moretti-Marques, Audrey Tieko Tsunoda, Vanessa Alvarenga-Bezerra, Andre Lopes, Ronaldo Lúcio Rangel Costa, Lillian Yuri Kumagai, Levon Badiglian-Filho, Carlos Chaves Faloppa, Henrique Mantoan, Louise De Brot, Ricardo Dos Reis, Bruna Tirapelli Goncalves

10.1136/ijgc-2022-003378

March 2, 2022

Phase 3, randomized, open-label study of pembrolizumab plus lenvatinib versus chemotherapy for first-line treatment of advanced or recurrent endometrial cancer: ENGOT-en9/LEAP-001

Christian Marth, Rafal Tarnawski, Alexandra Tyulyandina, Sandro Pignata, Lucy Gilbert, Diego Kaen, M Jesús Rubio, Sophia Frentzas, Mario Beiner, Manuel Magallanes-Maciel, Laura Farrelly, Chel Hun Choi, Regina Berger, Christine Lee, Christof Vulsteke, Kosei Hasegawa, Elena Ioanna Braicu, Xiaohua Wu, Jodi McKenzie, John J Lee, Vicky Makker

10.1136/ijgc-2021-003017

November 19, 2021

Randomized phase III trial on niraparib-TSR-042 (dostarlimab) versus physician’s choice chemotherapy in recurrent ovarian, fallopian tube, or primary peritoneal cancer patients not candidate for platinum retreatment: NItCHE trial (MITO 33)

Lucia Musacchio, Vanda Salutari, Sandro Pignata, Elena Braicu, David Cibula, Nicoletta Colombo, Jean Sebastien Frenel, Flora Zagouri, Vittoria Carbone, Viola Ghizzoni, Serena Giolitto, Elena Giudice, Maria Teresa Perri, Caterina Ricci, Giovanni Scambia, Domenica Lorusso

10.1136/ijgc-2021-002593

October 4, 2021

ATHENA (GOG-3020/ENGOT-ov45): a randomized, phase III trial to evaluate rucaparib as monotherapy (ATHENA–MONO) and rucaparib in combination with nivolumab (ATHENA–COMBO) as maintenance treatment following frontline platinum-based chemotherapy in ovarian cancer

Bradley J Monk, Robert L Coleman, Keiichi Fujiwara, Michelle K Wilson, Amit M Oza, Ana Oaknin, David M O’Malley, Domenica Lorusso, Shannon N Westin, Tamar Safra, Thomas J Herzog, Frederik Marmé, Ramez N Eskander, Kevin K Lin, Danny Shih, Sandra Goble, Nikolay Grechko, Stephanie Hume, Lara Maloney, Iain A McNeish, Rebecca S Kristeleit

10.1136/ijgc-2021-002933

September 30, 2021