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  • 2022-RA-586-ESGO The impact of the pattern of recurrence on post-relapse survival according to surgical timing in patients with advanced ovarian cancer

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Ovarian cancer
2022-RA-586-ESGO The impact of the pattern of recurrence on post-relapse survival according to surgical timing in patients with advanced ovarian cancer
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  1. Martina Aida Angeles1,
  2. Emanuela Spagnolo2,
  3. Bastien Cabarrou3,
  4. Asunción Pérez-Benavente4,
  5. Antonio Gil-Moreno4,
  6. Frédéric Guyon5,
  7. Agnieszka Rychlik6,
  8. Federico Migliorelli7,
  9. Guillaume Bataillon8,
  10. Anne-Sophie Navarro1,
  11. Sarah Bétrian9,
  12. Gwénaël Ferron1,
  13. Alicia Hernández2 and
  14. Alejandra Martinez1
  1. 1Department of Surgical Oncology, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, France
  2. 2Hospital La Paz, Madrid, Spain
  3. 3Biostatistics Unit, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, France
  4. 4Hospital Vall d’Hebron, Barcelona, Spain
  5. 5Institut Bergonié, Bordeaux, France
  6. 6Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland
  7. 7Paule de Viguier Hospital, Toulouse University Hospital, Toulouse, France
  8. 8Department of Anatomopathology, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, France
  9. 9Department of Oncology, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse, France

Abstract

Introduction/Background Our study aimed to evaluate the association between the timing of cytoreductive surgery (CRS) and the pattern of presentation of the first recurrence in patients with advanced ovarian cancer who underwent CRS. We also aimed to assess the impact of the pattern of recurrence on post-relapse overall survival (OS2) according to surgical timing.

Methodology This retrospective multicenter study evaluated patients with IIIC-IV FIGO stage ovarian cancer who underwent either primary debulking surgery (PDS), early interval debulking surgery (IDS) after 3–4 cycles of neoadjuvant chemotherapy (NACT), or delayed debulking surgery (DDS) after 6 cycles with minimal or no residual disease, between January 2008 and December 2015. Survival analyses were conducted using the Logrank test and the Cox model. Cumulative incidences of the different patterns of recurrence were estimated using a competing risks methodology.

Results A total of 549 patients were included: 175(31.9%) had PDS, 224(40.8%) early-IDS, and 150(27.3%) DDS. The cumulative incidence of peritoneal recurrences at two years was higher with increasing NACT cycles (PDS 24.4%, early-IDS 30.9%, DDS 39.2%; p=0.019). For pleural or pulmonary recurrences, it was higher after early-IDS (PDS 9.9%, early-IDS 13.0%, DDS 4.1%; p=0.022). Median OS2 was 33.5 months (95%CI [24.3–44.2]), 26.8 months (95%CI [22.8–32.6]), and 24.5 months (95%CI [18.6–29.4]) for PDS, early-IDS, and DDS groups, respectively (p=0.025). The pattern of the first recurrence (lymph node: HR 0.42, 95%CI [0.27–0.64]), surgical timing (DDS: HR 1.53, 95%CI [1.11–2.13]) and time to first recurrence (HR 0.95, 95%CI [0.93–0.96]) were associated with OS2. For PDS and early-IDS, lymph node recurrences were associated with significantly longer OS2.

Abstract 2022-RA-586-ESGO Figure 1
Abstract 2022-RA-586-ESGO Figure 1

Cumulative incidence of the pattern of recurrence by tumor location in the overall cohort

Abstract 2022-RA-586-ESGO Figure 2
Abstract 2022-RA-586-ESGO Figure 2

Overall survival post-relapse (OS2) according to the pattern of recurrence

Conclusion The pattern of first recurrence was associated with surgical timing, with peritoneal recurrences being more frequent after NACT. Lymph node recurrences were associated with better prognosis, having higher OS2, and was more marked after PDS and early-IDS.

https://doi.org/10.1136/ijgc-2022-ESGO.517

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