Poly (ADP-ribose) polymerase (PARP) is responsible for post-translational modification of
proteins in the response to numerous endogenous and environmental genotoxic agents …

Nitric-oxide synthases (NOSs, EC 1.14. 13.39) 1 oxidize L-arginine to nitric oxide (NO) and
are interesting for several reasons. They are present in many life forms (1, 2), their gene …

The renin-angiotensin system is a major physiological regulator of body fluid volume,
electrolyte balance, and arterial pressure. Virtually all of the biological actions of the …

Background Long-term exposure to ultraviolet irradiation from sunlight causes premature
skin aging (photoaging), characterized in part by wrinkles, altered pigmentation, and loss of …

DAMAGE to skin collagen and elastin (extracellular matrix) is the hallmark of long-term
exposure to solar ultraviolet irradiation1–3, and is believed to be responsible for the …

Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant
mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was …

Aim: Thalassaemia is a good candidate disease for control by preventive genetic
programmes in developing countries. Accurate population frequency data are needed for …

Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been
implicated as mediators of neuronal damage following focal ischemia, but their molecular …

THE proto-oncogene c-fos is the cellular homologue of v-fos originally isolated from murine
osteosarcoma1. Fos protein is a major component of the AP-1 transcription factor complex …

Poly (ADP-ribosyl) ation is catalyzed by NAD+: protein (ADP-ribosyl) transferase (ADPRT), a
chromatin-associated enzyme which, in the presence of DNA breaks, transfers ADP-ribose …