Ovarian cancer is the most lethal of malignant gynecological tumors. Its lethality may be due
to difficulties in detecting it at an early stage and lack of effective treatments for patients with …

Ovarian cancer is the leading cause of death among gynecologic malignancies. Since
ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and …

Peritoneal dissemination is a distinct form of metastasis in ovarian cancer that precedes
hematogenic or lymphatic metastasis. Exosomes are extracellular vesicles of 30–150 nm in …

Ovarian cancer (OVCA) inevitably acquires resistance to platinum chemotherapy and PARP
inhibitors (PARPi). We show that acquisition of PARPi-resistance is accompanied by …

Epithelial ovarian cancer (EOC) cells metastasize within the peritoneal cavity and directly
encounter human peritoneal mesothelial cells (HPMC) as the initial step of metastasis. The …

Ovarian cancer is characterized by widespread peritoneal dissemination and ascites and
has a cure rate of only 30%. As has been previously reported, integrin α5 plays a key role in …

Background microRNAs (miRNAs) stably exist in circulating blood and are encapsulated in
extracellular vesicles such as exosomes. The aims of this study were to identify which …

MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS)
miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to …

Ovarian cancer is largely diagnosed at advanced stages upon detection of multiple
peritoneal dissemination, resulting in poor outcomes. CD47 is overexpressed in tumors …

To improve our understanding of ovarian cancer, we performed genome-wide analyses of
45 ovarian cancer cell lines. Given the challenges of genomic analyses of tumors without …