[HTML][HTML] CRISPR/Cas9‑mediated cervical cancer treatment targeting human papillomavirus E6

T Yoshiba, Y Saga, M Urabe, R Uchibor… - Oncology …, 2019 - spandidos-publications.com
High‑risk human papillomavirus (HPV) is a common cause of cervical cancer. HPV E6
oncoprotein promotes the degradation of host tumor suppressor gene p53, leading to the …

NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites

R Uchibori, T Tsukahara, H Mizuguchi, Y Saga… - Cancer research, 2013 - AACR
Mesenchymal stem cells (MSC) accumulate at tumor sites when injected into tumor-bearing
mice, perhaps offering cellular vectors for cancer-targeted gene therapy. However, the …

Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer

T Kohno, H Mizukami, M Suzuki, Y Saga, Y Takei… - Cancer Research, 2003 - AACR
Abstract Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by T
lymphocytes and drawing attention as an inhibitor of tumor angiogenesis. In this study, we …

Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis

Y Takahashi, T Koyanagi, Y Suzuki, Y Saga… - Molecular Cancer …, 2012 - AACR
Abstract Vasohibin-1 (VASH1) is a VEGF-inducible endothelium-derived angiogenesis
inhibitor and VASH2 is its homolog. Our previous analysis revealed that VASH1 is …

[HTML][HTML] Indoleamine-2, 3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy

D Wang, Y Saga, H Mizukami… - International …, 2012 - spandidos-publications.com
This study examined the role of the immunosuppressive enzyme indoleamine-2, 3-
dioxygenase (IDO) in ovarian cancer progression, and the possible application of this …

Is peritoneal cytology a prognostic factor of endometrial cancer confined to the uterus?

Y Saga, M Imai, T Jobo, H Kuramoto, K Takahashi… - Gynecologic …, 2006 - Elsevier
OBJECTIVE.: The goal of this study was to investigate whether intraoperative peritoneal
cytology serves as a prognostic factor in patients with the endometrial cancer limited to the …

[HTML][HTML] Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase

M Suzuki, H Kobayashi, N Kanayama, Y Saga… - Journal of Biological …, 2004 - ASBMB
Urokinase-type plasminogen activator (uPA) degrades the extracellular matrix and plays
critical roles in tumor invasion and metastasis. Matriptase, a membrane-bound serine …

Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma

Y Saga, M Ohwada, M Suzuki, R Konno… - Oncology …, 2008 - spandidos-publications.com
Ovarian clear cell adenocarcinoma has low sensitivity to platinum drugs. The molecular-
biological mechanism of the low sensitivity has not been clarified. The objective of this study …

Indoleamine 2, 3-dioxygenase promotes peritoneal dissemination of ovarian cancer through inhibition of natural killercell function and angiogenesis promotion

H Nonaka, Y Saga, H Fujiwara… - International …, 2011 - spandidos-publications.com
The purpose of this study was to clarify the relationship between ovarian cancer peritoneal
dissemination and indoleamine 2, 3-dioxygenase (IDO) expression, and to explore the …

[HTML][HTML] Downregulation of indoleamine-2, 3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation

N Sato, Y Saga, H Mizukami, D Wang… - Oncology …, 2012 - spandidos-publications.com
This study examined the role of the immunosuppressive enzyme indoleamine-2, 3-
dioxygenase (IDO) in cervical cancer progression and the possible use of this enzyme for …