[HTML][HTML] Oleic acid exhibits anti-proliferative and anti-invasive activities via the PTEN/AKT/mTOR pathway in endometrial cancer

B Deng, W Kong, H Suo, X Shen, MA Newton… - Cancers, 2023 - mdpi.com
Simple Summary Metabolic reprogramming, especially fatty acid metabolism, is very
strongly associated with carcinogenesis and progression of endometrial cancer. Increasing …

[HTML][HTML] An evaluation of the microbiota of the upper reproductive tract of women with and without epithelial ovarian cancer

WR Brewster, WC Burkett, EM Ko, V Bae-Jump… - Gynecologic Oncology …, 2022 - Elsevier
Objective The microbiome of the female upper reproductive tract (URT) has not been
characterized. We hypothesize that distinct bacterial species may be identified in different …

The interplay of obesity, microbiome dynamics, and innovative anti-obesity strategies in the context of endometrial cancer progression and therapeutic approaches

WC Burkett, AD Clontz, TO Keku… - Biochimica et Biophysica …, 2023 - Elsevier
Endometrial cancer (EC) is the most common gynecologic malignancy in the United States,
and its incidence and mortality are rising. Obesity is more tightly associated with EC than …

A review of current management of placental site trophoblastic tumor and epithelioid trophoblastic tumor

WC Burkett, JT Soper - Obstetrical & Gynecological Survey, 2022 - journals.lww.com
A Review of Current Management of Placental Site Trophoblast... : Obstetrical & Gynecological
Survey A Review of Current Management of Placental Site Trophoblastic Tumor and Epithelioid …

[HTML][HTML] Differences in the microbial profiles of early stage endometrial cancers between Black and White women

GM Hawkins, WC Burkett, AN McCoy, HB Nichols… - Gynecologic …, 2022 - Elsevier
Objective Black women suffer a higher mortality from endometrial cancer (EC) than White
women. Potential biological causes for this disparity include a higher prevalence of obesity …

Adjuvant therapy for early stage, endometrial cancer with lymphovascular space invasion: is there a role for chemotherapy?

AL Beavis, TT Yen, RL Stone, SL Wethington… - Gynecologic …, 2020 - Elsevier
Objectives Lymphovascular space invasion (LVSI) is an independent risk factor for
recurrence and poor survival in early-stage endometrioid endometrial cancer (EEC), but …

Ipatasertib, an oral AKT inhibitor, in combination with carboplatin exhibits anti-proliferative effects in uterine serous carcinoma

WC Burkett, Z Zhao, MA Newton, W Sun… - Annals of …, 2023 - Taylor & Francis
Purpose Uterine serous carcinoma (USC) exhibits worse survival rates compared to the
endometrioid subtype, and there is currently no effective treatment options for recurrence of …

Adjuvant treatment improves overall survival in women with high-intermediate risk early-stage endometrial cancer with lymphovascular space invasion

J Son, LM Chambers, C Carr, CM Michener… - International Journal of …, 2020 - ijgc.bmj.com
Background Adjuvant therapy in early-stage endometrial cancer has not shown a clear
overall survival benefit, and hence, patient selection remains crucial. Objective To determine …

Extending the platinum-free interval: the impact of omitting 2nd line platinum chemotherapy in intermediate platinum-sensitive ovarian cancer

LE Dockery, AR Rubenstein, K Ding, SG Mashburn… - Gynecologic …, 2019 - Elsevier
Objectives Patients with epithelial ovarian cancer (EOC) recurring between 6 and 12 months
after primary platinum chemotherapy have worse prognosis than those recurring in> 12 …

Fractured and delayed: A qualitative analysis of disruptions in care for gynecologic malignancies during incarceration

WC Burkett, Y Iwai, PA Gehrig, AK Knittel - Gynecologic Oncology, 2023 - Elsevier
Objective Women are experiencing growing rates of incarceration at twice the pace of that
for men. Additionally, one-third will be older than 55 years of age by the end of the decade …