SBML Level 3: an extensible format for the exchange and reuse of biological models
Abstract Systems biology has experienced dramatic growth in the number, size, and
complexity of computational models. To reproduce simulation results and reuse models …
complexity of computational models. To reproduce simulation results and reuse models …
The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key events in the
development of glioma, acute myeloid leukemia (AML), chondrosarcoma, intrahepatic …
development of glioma, acute myeloid leukemia (AML), chondrosarcoma, intrahepatic …
Dynamics of clonal evolution in myelodysplastic syndromes
To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …
12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumors
T Korytko, T Radivoyevitch, V Colussi… - International Journal of …, 2006 - Elsevier
Purpose: To determine whether the 12-Gy radiosurgical volume (12-GyV) correlates with the
development of postradiosurgical imaging changes suggestive of radiation necrosis in …
development of postradiosurgical imaging changes suggestive of radiation necrosis in …
Genetic alterations of the cohesin complex genes in myeloid malignancies
Somatic cohesin mutations have been reported in myelodysplastic syndrome (MDS) and
acute myeloid leukemia (AML). To account for the morphologic and cytogenetic diversity of …
acute myeloid leukemia (AML). To account for the morphologic and cytogenetic diversity of …
[HTML][HTML] Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis
TJ Alban, AG Alvarado, MD Sorensen, D Bayik… - JCI insight, 2018 - ncbi.nlm.nih.gov
Glioblastoma (GBM) remains uniformly lethal, and despite a large accumulation of immune
cells in the microenvironment, there is limited antitumor immune response. To overcome …
cells in the microenvironment, there is limited antitumor immune response. To overcome …
Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
RJ Molenaar, D Botman, MA Smits, VV Hira… - Cancer research, 2015 - AACR
Abstract Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to
IDH1R132H, a structural alteration that leads to catalysis of α-ketoglutarate to the …
IDH1R132H, a structural alteration that leads to catalysis of α-ketoglutarate to the …
p53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignancies
Cytotoxic chemotherapy for acute myeloid leukemia (AML) usually produces only temporary
remissions, at the cost of significant toxicity and risk for death. One fundamental reason for …
remissions, at the cost of significant toxicity and risk for death. One fundamental reason for …
[HTML][HTML] Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: a randomized phase 1 study
R Molokie, D Lavelle, M Gowhari, M Pacini… - PLoS …, 2017 - journals.plos.org
Background Sickle cell disease (SCD), a congenital hemolytic anemia that exacts terrible
global morbidity and mortality, is driven by polymerization of mutated sickle hemoglobin …
global morbidity and mortality, is driven by polymerization of mutated sickle hemoglobin …
[HTML][HTML] Risk of hematologic malignancies after radioiodine treatment of well-differentiated thyroid cancer
Purpose To investigate the risk and outcomes of second hematologic malignancies (SHMs)
in a population-based cohort of patients with well-differentiated thyroid cancer (WDTC) …
in a population-based cohort of patients with well-differentiated thyroid cancer (WDTC) …