Glioblastomas are malignant brain tumors with dismal prognosis despite standard treatment
with surgery and radio/chemotherapy. These tumors are defined by an important cellular …

Metastasis is the main cause of death for patients with breast cancer. Many studies have
characterized the genomic landscape of breast cancer during its early stages. However …

Purpose Approximately 1% of lung adenocarcinomas are driven by oncogenic ROS1
rearrangement. Crizotinib is a potent inhibitor of both ROS1 and ALK kinase domains …

Background Breast cancer is characterised by genomic alterations. We did a multicentre
molecular screening study to identify abnormalities in individual patients with the aim of …

The mechanisms of action of and resistance to trastuzumab deruxtecan (T-DXd), an anti-
HER2–drug conjugate for breast cancer treatment, remain unclear. The phase 2 DAISY trial …

Background: Venous problems are the most frequent causes of flap failure and surgical
revision in free flap surgery. Double venous anastomosis can be used to improve flap …

The mechanisms governing infiltration of lymphocytes into tumors remain poorly
characterized, in spite of the critical impact of these cells on patient prognosis and …

Background Major advances have been achieved in the characterization of early breast
cancer (eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor …

Purpose In addition to prospective trials for non–small-cell lung cancers (NSCLCs) that are
driven by less common genomic alterations, registries provide complementary information …

Antibodies against programmed cell death-1 (PD-1) have considerably changed the
treatment for melanoma. However, many patients do not display therapeutic response or …