User profiles for "author:Takeshi Nagashima"
 | Takeshi NagashimaSetsunan University Verified email at mpg.setsunan.ac.jp Cited by 2157 |
[HTML][HTML] Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
EH Kobayashi, T Suzuki, R Funayama… - Nature …, 2016 - nature.com
Abstract Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic
stress response and also represses inflammation. However, the mechanisms how Nrf2 …
stress response and also represses inflammation. However, the mechanisms how Nrf2 …
Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks
Y Hirotsu, F Katsuoka, R Funayama… - Nucleic acids …, 2012 - academic.oup.com
Abstract NF-E2-related factor 2 (Nrf2) is a key transcription factor that is critical for cellular
defense against oxidative and xenobiotic insults. Nrf2 heterodimerizes with small Maf (sMaf) …
defense against oxidative and xenobiotic insults. Nrf2 heterodimerizes with small Maf (sMaf) …
[PDF][PDF] Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome
Y Aoki, T Niihori, T Banjo, N Okamoto, S Mizuno… - The American Journal of …, 2013 - cell.com
RAS GTPases mediate a wide variety of cellular functions, including cell proliferation,
survival, and differentiation. Recent studies have revealed that germline mutations and …
survival, and differentiation. Recent studies have revealed that germline mutations and …
Stromal MCP‐1 in mammary tumors induces tumor‐associated macrophage infiltration and contributes to tumor progression
H Fujimoto, T Sangai, G Ishii, A Ikehara… - … journal of cancer, 2009 - Wiley Online Library
There is growing evidence that tumor‐associated macrophages (TAMs) promote tumor
growth and dissemination. Many individual reports have focused on the protumor function of …
growth and dissemination. Many individual reports have focused on the protumor function of …
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory
T Kaji, A Ishige, M Hikida, J Taka, A Hijikata… - Journal of Experimental …, 2012 - rupress.org
One component of memory in the antibody system is long-lived memory B cells selected for
the expression of somatically mutated, high-affinity antibodies in the T cell–dependent …
the expression of somatically mutated, high-affinity antibodies in the T cell–dependent …
[HTML][HTML] Human genetic variation database, a reference database of genetic variations in the Japanese population
K Higasa, N Miyake, J Yoshimura, K Okamura… - Journal of human …, 2016 - nature.com
Whole-genome and-exome resequencing using next-generation sequencers is a powerful
approach for identifying genomic variations that are associated with diseases. However …
approach for identifying genomic variations that are associated with diseases. However …
[HTML][HTML] Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics
T Nakakuki, MR Birtwistle, Y Saeki, N Yumoto, K Ide… - Cell, 2010 - cell.com
Activation of ErbB receptors by epidermal growth factor (EGF) or heregulin (HRG)
determines distinct cell-fate decisions, although signals propagate through shared …
determines distinct cell-fate decisions, although signals propagate through shared …
The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin
T Hidaka, E Ogawa, EH Kobayashi, T Suzuki… - Nature …, 2017 - nature.com
Atopic dermatitis is increasing worldwide in correlation with air pollution. Various organic
components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor) …
components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor) …
Predicting the prognoses of breast carcinoma patients with positron emission tomography using 2‐deoxy‐2‐fluoro[18F]‐D‐glucose
M Oshida, K Uno, M Suzuki… - … Journal of the …, 1998 - Wiley Online Library
BACKGROUND Positron emission tomography (PET) with 2‐deoxy‐2‐fluoro [18F]‐D‐
glucose (FDG) can provide quantitative information about tumor glucose metabolism. The …
glucose (FDG) can provide quantitative information about tumor glucose metabolism. The …
[HTML][HTML] Quantitative transcriptional control of ErbB receptor signaling undergoes graded to biphasic response for cell differentiation
T Nagashima, H Shimodaira, K Ide, T Nakakuki… - Journal of biological …, 2007 - ASBMB
ErbB receptor ligands, epidermal growth factor (EGF) and heregulin (HRG), induce dose-
dependent transient and sustained intracellular signaling, proliferation, and differentiation of …
dependent transient and sustained intracellular signaling, proliferation, and differentiation of …