The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and …
H Kitamura, K Iwakabe, T Yahata… - The Journal of …, 1999 - rupress.org
The natural killer T (NKT) cell ligand α-galactosylceramide (α-GalCer) exhibits profound
antitumor activities in vivo that resemble interleukin (IL)-12–mediated antitumor activities …
antitumor activities in vivo that resemble interleukin (IL)-12–mediated antitumor activities …
Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo
…, K Iwakabe, M Sekimoto, Y Ohmi, T Yahata… - The Journal of …, 1999 - rupress.org
The role of T helper type 1 (Th1) and Th2 cells in tumor immunity was investigated using Th
cells induced from ovalbumin (OVA)-specific T cell receptor transgenic mice. Although Th1 …
cells induced from ovalbumin (OVA)-specific T cell receptor transgenic mice. Although Th1 …
Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment
Y Muguruma, T Yahata, H Miyatake, T Sato, T Uno… - Blood, 2006 - ashpublications.org
Hematopoiesis is maintained by specific interactions between both hematopoietic and
nonhematopoietic cells. Whereas hematopoietic stem cells (HSCs) have been extensively …
nonhematopoietic cells. Whereas hematopoietic stem cells (HSCs) have been extensively …
Delta-like 4 is indispensable in thymic environment specific for T cell development
…, C Mailhos, N Negishi, K Hirano, T Yahata… - The Journal of …, 2008 - rupress.org
The thymic microenvironment is required for T cell development in vivo. However, in vitro
studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta …
studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta …
Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells
T Yahata, T Takanashi, Y Muguruma… - Blood, The Journal …, 2011 - ashpublications.org
Stem cells of highly regenerative organs including blood are susceptible to endogenous
DNA damage caused by both intrinsic and extrinsic stress. Response mechanisms to such …
DNA damage caused by both intrinsic and extrinsic stress. Response mechanisms to such …
The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of …
…, H Kitamura, K Iwakabe, T Yahata… - International …, 2000 - academic.oup.com
In vivo administration of NKT cell ligand, α-galactosylceramide (α-GalCer), caused the
activation of NKT cells to induce a strong NK activity and cytokine production by CD1d …
activation of NKT cells to induce a strong NK activity and cytokine production by CD1d …
[HTML][HTML] Renocardiovascular biomarkers: from the perspective of managing chronic kidney disease and cardiovascular disease
S Niizuma, Y Iwanaga, T Yahata… - Frontiers in cardiovascular …, 2017 - frontiersin.org
Mortality among the patients with chronic kidney disease (CKD) and end-stage renal
disease (ESRD) remains high because of the very high incidence of cardiovascular disease …
disease (ESRD) remains high because of the very high incidence of cardiovascular disease …
Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor γ null mice
T Yahata, K Ando, Y Nakamura, Y Ueyama… - The Journal of …, 2002 - journals.aai.org
An experimental model for human T lymphocyte development from hemopoietic stem cells is
necessary to study the complex processes of T cell differentiation in vivo. In this study, we …
necessary to study the complex processes of T cell differentiation in vivo. In this study, we …
[HTML][HTML] The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain
MP De Caestecker, T Yahata, D Wang… - Journal of Biological …, 2000 - ASBMB
Transforming growth factor-β (TGF-β) family members signal through a unique set of
intracellular proteins called Smads. Smad4, previously identified as the tumor …
intracellular proteins called Smads. Smad4, previously identified as the tumor …
A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow
T Yahata, K Ando, T Sato, H Miyatake… - Blood, The Journal …, 2003 - ashpublications.org
To measure the ability of human hematopoietic stem cells (HSCs), the SCID-repopulating
cell (SRC) assay has been widely used. Conventionally, human HSCs are transplanted into …
cell (SRC) assay has been widely used. Conventionally, human HSCs are transplanted into …