Sulfated sugars in the extracellular matrix orchestrate ovarian cancer development:'When sweet turns sour'
MJE Vallen, SCHA van der Steen, AAG van Tilborg… - Gynecologic …, 2014 - Elsevier
Considering the high mortality of ovarian cancer, novel approaches for diagnostics and
therapy are urgently needed. Cancer initiation, progression, and invasion occur in a …
therapy are urgently needed. Cancer initiation, progression, and invasion occur in a …
[HTML][HTML] Targeting the extracellular matrix of ovarian cancer using functionalized, drug loaded lyophilisomes
SCHA van der Steen, R Raavé, S Langerak… - European Journal of …, 2017 - Elsevier
Epithelial ovarian cancer is characterized by a high mortality rate and is in need for novel
therapeutic avenues to improve patient outcome. The tumor's extracellular matrix (“stroma”) …
therapeutic avenues to improve patient outcome. The tumor's extracellular matrix (“stroma”) …
Prognostic significance of highly sulfated chondroitin sulfates in ovarian cancer defined by the single chain antibody GD3A11
SCHA van der Steen, AAG van Tilborg, MJE Vallen… - Gynecologic …, 2016 - Elsevier
Objective The extracellular matrix (ECM) of ovarian cancer may provide a number of
potential biomarkers. Chondroitin sulfate (CS), a class of sulfated polysaccharides, is …
potential biomarkers. Chondroitin sulfate (CS), a class of sulfated polysaccharides, is …
Changes in the extracellular matrix are associated with the development of serous tubal intraepithelial carcinoma into high-grade serous carcinoma
SCHA van der Steen, J Bulten… - International Journal of …, 2017 - ijgc.bmj.com
Objective The identification of a marker for early progression of preinvasive lesions into
invasive pelvic high-grade serous carcinoma (HGSC) may provide novel handles for …
invasive pelvic high-grade serous carcinoma (HGSC) may provide novel handles for …
Primary Ovarian Tumors With Lymphogenic and Hematogenic Metastasis Express High MMP-14, Which Colocalizes With Highly Sulfated Chondroitin Sulfate in the …
MC Vos, E Hollemans… - International Journal …, 2020 - journals.lww.com
Lymphogenic and hematogenic metastases are uncommon in ovarian cancer, especially at
presentation. We hypothesized that MMP-14 and MMP-2, CD44, and highly sulfated …
presentation. We hypothesized that MMP-14 and MMP-2, CD44, and highly sulfated …
[PDF][PDF] Exploring the clinical relevance of chondroitin sulfate in the ovarian cancer microenvironment
SCHA van der Steen - 2017 - repository.ubn.ru.nl
Ovarian cancer is a major health threat in women, causing more deaths than all other
gynecologic cancers combined. Worldwide, about 226,000 new patients and approximately …
gynecologic cancers combined. Worldwide, about 226,000 new patients and approximately …
[PDF][PDF] Infiltrating T cells within the serous tubal intra-epithelial carcinoma (STIC) microenvironment
SCHA van der Steen, C Wefers… - PDF hosted at the …, 2017 - repository.ubn.ru.nl
The host immunological anti-cancer response comprises a complex and dynamic interplay
between various immune factors, and may either negatively or positively affect high grade …
between various immune factors, and may either negatively or positively affect high grade …
[PDF][PDF] T Cell Infiltration in Serous Tubal Intraepithelial Carcinoma (STIC)
C Wefers, SCHA van der Steen, MAJ Gorris… - The role of the immune … - repository.ubn.ru.nl
The anti-tumor immune response comprises a complex and dynamic interplay between
various immune factors, and may either negatively or positively affect high-grade serous …
various immune factors, and may either negatively or positively affect high-grade serous …