Background Germline truncating mutations in DICER1, an endoribonuclease in the RNase
III family that is essential for processing microRNAs, have been observed in families with the …

Ovarian carcinomas are thought to arise in the ovarian surface epithelium (OSE). Although
this tissue forms a simple epithelial covering on the ovarian surface, OSE cells exhibit some …

The ovarian surface epithelium (OSE) is the precursor of common epithelial ovarian
carcinomas. In the present study, we examined the molecular mechanisms and possible …

Background The ovarian surface epithelium (OSE) is a modified mesothelium that gives rise
to most human ovarian carcinomas. In culture, OSE cells tend to assume atypical …

OBJECTIVE: We aimed to improve the availability of experimental models for the study of
human ovarian surface epithelium. STUDY DESIGN: Low-passage cultures of human …

Background A somatic mutation in the FOXL2 gene is reported to be present in almost all
(97%; 86/89) morphologically defined, adult-type, granulosa-cell tumors (A-GCTs). This …

Ovarian surface epithelium (OSE), the source of common epithelial carcinomas, is a simple
mesothelium that during carcinogenesis acquires complex epithelial characteristics normally …

Introduction: Epithelial ovarian carcinomas are highly lethal because most are detected at
late stages. A previous immunohistochemical analysis showed that oviductal glycoprotein 1 …

Epithelial ovarian carcinomas originate in the ovarian surface epithelium (OSE). In culture,
OSE undergoes epithelio‐mesenchymal conversion, an event mimicking a wound response …

DICER1 plays a critical role in microRNA (miRNA) biogenesis. Recurrent somatic'hotspot'
mutations at the four metal‐binding sites within the RNase IIIb domain of DICER1 were …