During cancer progression and treatment, multiple subclonal populations of tumour cells
compete with one another, with selective pressures leading to the emergence of …

Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need,
especially as diagnosis in this population might lead to the greatest loss of years of life …

Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of
circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a …

Purpose Prior reports have indicated that patients with colon cancer who demonstrate high-
level microsatellite instability (MSI-H) or defective DNA mismatch repair (dMMR) have …

Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and
clonal evolution. The molecular profile of CRC is routinely assessed in surgical or bioptic …

Background We previously found that dual HER2 blockade with trastuzumab and lapatinib
led to inhibition of tumour growth in patient-derived xenografts of HER2-amplified metastatic …

Only a fraction of patients with metastatic colorectal cancer receive clinical benefit from
therapy with anti-epidermal growth factor receptor (EGFR) antibodies, which calls for the …

Objective.—To assess prospectively the impact on survival and health-related quality of life
of two follow-up protocols in patients with early breast cancer. Design.—Randomized …

Background Approximately 15% of colorectal cancers develop because of defective function
of the DNA mismatch repair (MMR) system. We determined the association of MMR status …

Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer
initiation and foster tumour progression. Cancers deficient in MMR frequently show …