Background Donor-specific antibodies create an immunologic barrier to transplantation.
Current therapies to modify donor-specific antibodies are limited and ineffective in the most …

IdeS is a streptococcal protease that cleaves IgG antibodies into F (ab') 2 and Fc fragments
with a unique degree of specificity, thereby providing a novel treatment opportunity of IgG …

Safety, immunogenicity, pharmacokinetics, and efficacy of the IgG-degrading enzyme of
Streptococcus pyogenes (IdeS [imlifidase]) were assessed in a single-center, open-label …

Mesenchymal stem cells (MSCs) are multipotent cells that have the capacity to differentiate
into various different cell lineages and can generate bone, cartilage and adipose tissue …

Myxoid/round cell liposarcoma (MLS/RCLS) is the most common subtype of liposarcoma.
Most MLS/RCLS carry at (12; 16) translocation, resulting in a FUS-DDIT3 fusion gene. We …

Ag binding to the BCR is a critical step in B cell development and activation, initiating a
cascade of signaling events ultimately leading to proliferation, differentiation, or cell death. A …

Background. Imlifidase is an immunoglobulin G (IgG)-specific protease conditionally
approved in the EU for desensitization in highly sensitized crossmatch positive kidney …

Autoantibodies binding to peripheral nerves followed by complement deposition and
membrane attack complex formation results in nerve damage in Guillain-Barré syndrome …

We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to
the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene …

Infectious diseases are characterized by a complex interplay between host and pathogen,
but how these interactions impact the host proteome is unclear. Here we applied a …