[HTML][HTML] Targeting the ATR-CHK1 axis in cancer therapy
S Rundle, A Bradbury, Y Drew, NJ Curtin - Cancers, 2017 - mdpi.com
Targeting the DNA damage response (DDR) is a new therapeutic approach in cancer that
shows great promise for tumour selectivity. Key components of the DDR are the ataxia …
shows great promise for tumour selectivity. Key components of the DDR are the ataxia …
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member
JD Brook, ME McCurrach, HG Harley, AJ Buckler… - Cell, 1992 - cell.com
Using positional cloning strategies, we have identified a CTG triplet repeat that undergoes
expansion in myotonic dystrophy patients. This sequence is highly variable in the normal …
expansion in myotonic dystrophy patients. This sequence is highly variable in the normal …
The consequences of doing nothing: The effects of seawater flooding on coastal zones
SPG Hoggart, ME Hanley, DJ Parker, DJ Simmonds… - Coastal …, 2014 - Elsevier
Sea level rise and an increased frequency and severity of storm surge events due to climate
change are likely to increase the susceptibility of low lying coastal areas to seawater …
change are likely to increase the susceptibility of low lying coastal areas to seawater …
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy
HG Harley, JD Brook, SA Rundle, S Crow, W Reardon… - Nature, 1992 - nature.com
Abstract MYOTONIC Received 2 December 1991; accepted 7 January 1992. dystrophy is
the commonest adult form of muscular dystrophy, with an estimated incidence of 1 per 7,500 …
the commonest adult form of muscular dystrophy, with an estimated incidence of 1 per 7,500 …
Threats to the running water ecosystems of the world
B Malmqvist, S Rundle - Environmental conservation, 2002 - cambridge.org
Running waters are perhaps the most impacted ecosystem on the planet as they have been
the focus for human settlement and are heavily exploited for water supplies, irrigation …
the focus for human settlement and are heavily exploited for water supplies, irrigation …
Size of the unstable CTG repeat sequence in relation to phenotype and parental transmission in myotonic dystrophy.
HG Harley, SA Rundle, JC MacMillan… - American journal of …, 1993 - ncbi.nlm.nih.gov
A clinical and molecular analysis of 439 individuals affected with myotonic dystrophy, from
101 kindreds, has shown that the size of the unstable CTG repeat detected in nearly all …
101 kindreds, has shown that the size of the unstable CTG repeat detected in nearly all …
Hormone replacement therapy for women previously treated for endometrial cancer
KA Edey, S Rundle, M Hickey - Cochrane Database of …, 2018 - cochranelibrary.com
Background Endometrial cancer is the sixth most common cancer in women worldwide and
most commonly occurs after the menopause (75%)(globocan. iarc. fr). About 319,000 new …
most commonly occurs after the menopause (75%)(globocan. iarc. fr). About 319,000 new …
Ecotone or ecocline: ecological boundaries in estuaries
MJ Attrill, SD Rundle - Estuarine, Coastal and Shelf Science, 2002 - Elsevier
Two main ecological boundaries, ecotone and ecocline, have been defined in landscape
ecology. At this scale, the estuary represents a boundary between rivers and the sea, but …
ecology. At this scale, the estuary represents a boundary between rivers and the sea, but …
Ocean acidification disrupts induced defences in the intertidal gastropod Littorina littorea
Carbon dioxide-induced ocean acidification is predicted to have major implications for
marine life, but the research focus to date has been on direct effects. We demonstrate that …
marine life, but the research focus to date has been on direct effects. We demonstrate that …
Comparing the strength of behavioural plasticity and consistency across situations: animal personalities in the hermit crab Pagurus bernhardus
Many phenotypic traits show plasticity but behaviour is often considered the 'most
plastic'aspect of phenotype as it is likely to show the quickest response to temporal changes …
plastic'aspect of phenotype as it is likely to show the quickest response to temporal changes …