Addressing the role of obesity in endometrial cancer risk, prevention, and treatment

MA Onstad, RE Schmandt, KH Lu - Obstetrical & Gynecological …, 2017 - journals.lww.com
The worldwide obesity epidemic has had a major impact on the health and well-being of
both men and women. Obesity is well established as a major causal factor for the …

Understanding obesity and endometrial cancer risk: opportunities for prevention

RE Schmandt, DA Iglesias, NN Co, KH Lu - American journal of obstetrics …, 2011 - Elsevier
Worldwide, obesity has become a major public health crisis. Overweight and obesity not
only increase the risk of cardiovascular disease and type-2 diabetes mellitus but also are …

[HTML][HTML] Dicer, Drosha, and outcomes in patients with ovarian cancer

WM Merritt, YG Lin, LY Han, AA Kamat… - … England Journal of …, 2008 - Mass Medical Soc
Background We studied Dicer and Drosha, components of the RNA-interference machinery,
in ovarian cancer. Methods We measured messenger RNA (mRNA) levels of Dicer and …

Therapeutic EphA2 Gene Targeting In vivo Using Neutral Liposomal Small Interfering RNA Delivery

CN Landen Jr, A Chavez-Reyes, C Bucana… - Cancer research, 2005 - AACR
Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool
in analysis of protein function, but its use as a therapeutic modality has been limited by …

[HTML][HTML] Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

CL Au Yeung, NN Co, T Tsuruga, TL Yeung… - Nature …, 2016 - nature.com
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum.
However, the omental stromal cell-derived molecular determinants that modulate ovarian …

Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis

KH Lu, AP Patterson, L Wang, RT Marquez… - Clinical cancer …, 2004 - AACR
Purpose: Advanced-stage epithelial ovarian cancer has a poor prognosis with long-term
survival in less than 30% of patients. When the disease is detected in stage I, more than …

[PDF][PDF] Regulation of tumor angiogenesis by EZH2

C Lu, HD Han, LS Mangala, R Ali-Fehmi, CS Newton… - Cancer cell, 2010 - cell.com
Although VEGF-targeted therapies are showing promise, new angiogenesis targets are
needed to make additional gains. Here, we show that increased Zeste homolog 2 (EZH2) …

Focal Adhesion Kinase Targeting Using In vivo Short Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy

J Halder, AA Kamat, CN Landen Jr, LY Han… - Clinical Cancer …, 2006 - AACR
Purpose: Focal adhesion kinase (FAK) plays a critical role in ovarian cancer cell survival
and in various steps in the metastatic cascade. Based on encouraging in vitro results with …

Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma

C Lu, T Bonome, Y Li, AA Kamat, LY Han, R Schmandt… - Cancer research, 2007 - AACR
Therapeutic strategies based on antiangiogenic approaches are beginning to show great
promise in clinical studies. However, full realization of these approaches requires …

Omental adipose tissue–derived stromal cells promote vascularization and growth of endometrial tumors

AH Klopp, Y Zhang, T Solley, F Amaya-Manzanares… - Clinical cancer …, 2012 - AACR
Purpose: Adipose tissue contains a population of tumor-tropic mesenchymal progenitors,
termed adipose stromal cells (ASC), which engraft in neighboring tumors to form supportive …