BACKGROUND: Intrauterine progesterone therapy potentially provides a simple alternative
treatment for women with Stage I Grade I endometrial cancers who are at high risk for …

Background Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5
years. We designed this trial to establish the effect of early detection by screening on ovarian …

Background Ovarian cancer continues to have a poor prognosis with the majority of women
diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of …

Background Ovarian cancer has a high case–fatality ratio, with most women not diagnosed
until the disease is in its advanced stages. The United Kingdom Collaborative Trial of …

Background The value of screening for ovarian cancer is uncertain. We did a pilot
randomised trial to assess multimodal screening with sequential CA 125 antigen and …

Background The high overall mortality from ovarian cancer (> 60%) relates, in part, to delays
in diagnosis. When ovarian cancer is detected in stage I (International Federation of …

Background The increase in the worldwide incidence of endometrial cancer relates to rising
obesity, falling fertility, and the ageing of the population. Transvaginal ultrasound (TVS) is a …

Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected
Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of …

Objective: To determine the risk of invasive epithelial ovarian cancer and fallopian tube
cancer associated with a raised concentration of the tumour marker CA 125 in asymptomatic …

Objective To validate a risk of malignancy index incorporating menopausal status, serum CA
125 level and pelvic ultrasound features in the pre‐operative diagnosis of ovarian cancer …