Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism

I Edery, R Petryshyn, N Sonenberg - Cell, 1989 - Elsevier
All mRNAs of human immunodeficiency virus 1 (HIV-1) contain in their 5′ untranslated
region a sequence termed TAR that responds to trans-activation by the tat (trans-activating) …

Characterization of double-stranded-RNA-activated kinase that phosphorylates α subunit of eukaryotic initiation factor 2 (eIF-2α) in reticulocyte lysates

DH Levin, R Petryshyn… - Proceedings of the …, 1980 - National Acad Sciences
Incubation of reticulocyte lysates with low levels of double-stranded (ds) RNA (1-20 ng/ml)
activates a cAMP-independent protein kinase (dsI) that phosphorylates the α-subunit (M r …

Disulfide Bond Formation in the Regulation of eIF-2 α Kinase by Heme

JJ Chen, JM Yang, R Petryshyn, N Kosower… - Journal of Biological …, 1989 - Elsevier
The inhibition of the autophosphorylation of the heme-regulated eukaryotic initiation factor
(eIF)-2α kinase (HRI) by hemin is very similar to that produced by thiol oxidation by diamide …

Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases.

JJ Chen, JK Pal, R Petryshyn, I Kuo… - Proceedings of the …, 1991 - National Acad Sciences
We have purified the heme-regulated eukaryotic initiation factor 2 alpha subunit (eIF-2
alpha) kinase (HRI) from rabbit reticulocytes for amino acid microsequencing. This kinase is …

Implementation of timeline reforms speeds initiation of national cancer institute–sponsored trials

JS Abrams, MM Mooney, JA Zwiebel… - Journal of the …, 2013 - academic.oup.com
Abstract Background The National Cancer Institute (NCI) organized the Operational
Efficiency Working Group in 2008 to develop recommendations for improving the speed with …

Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells.

R Petryshyn, JJ Chen… - Proceedings of the …, 1988 - National Acad Sciences
We have previously reported that cultured mouse 3T3-F442A cells exhibit a transient,
double-stranded RNA (dsRNA)-dependent phosphorylation of the dsRNA-dependent eIF-2 …

Current academic clinical trials in ovarian cancer: gynecologic cancer intergroup and US national cancer institute clinical trials planning meeting, May 2009

EL Trimble, MJ Birrer, WJ Hoskins, C Marth… - International Journal of …, 2010 - ijgc.bmj.com
Objective: To review the current status of large phase academic clinical trials for women with
ovarian cancer, address cross-cutting issues, and identify promising areas for future …

Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA.

NS Thomas, RL Matts, R Petryshyn… - Proceedings of the …, 1984 - National Acad Sciences
We have recently shown a direct correlation between protein synthetic activity and the
function of reversing factor (RF) as a catalyst of GDP-GTP exchange in whole reticulocyte …

Regulation of protein synthesis in reticulocyte lysates: immune serum inhibits heme-regulated protein kinase activity and differentiates heme-regulated protein kinase …

R Petryshyn, H Trachsel… - Proceedings of the …, 1979 - National Acad Sciences
A specific immune serum to the heme-regulated inhibitor (HRI) has been prepared by
immunizing chickens with highly purified reversible HRI prepared from rabbit reticulocyte …

[37] Double-stranded RNA-dependent eIF-2α protein kinase

R Petryshyn, DH Levin, IM London - Methods in Enzymology, 1983 - Elsevier
Publisher Summary This chapter describes the purification and characterization of the latent
form of the reticulocyte double-stranded RNA activated elF-2α kinase (dsI). At all stages of …