Germline mutations in LKB1 have been reported to underlie familial Peutz-Jeghers
syndrome (PJS) with intestinal hamartomatous polyps and an elevated risk of various …

Abstract Patients with Peutz‐Jeghers' syndrome (PJS) develop hamartomatous
gastrointestinal polyps and characteristic pigmentation, as a result of germline mutations in …

Human herpesvirus-8 (HHV-8) has been described in association with two
lymphoproliferative disorders: one benign, multicentric Castleman's disease (MCD), and one …

Objective. Low-grade mucinous tumors of the appendix appear to have a simple histological
structure. Paradoxically, reports have suggested a greater frequency of Ki-ras gene mutation …

A locus for Peutz-Jeghers syndrome (PJS) was recently mapped to chromosome 19p13. 3.
Each of 12 families studied was compatible with linkage to the marker D19S886. We have …

We have evaluated the frequency of KRAS gene mutations during the critical transition from
villous adenoma to colorectal carcinoma to assess whether the adenomas contain a KRAS …

Objective Endometrial cancer (EC) results from the accumulation of numerous genetic
abnormalities contributing to the progression from hyperplasia to EC. Information on these …

Mutations of the gene GNAS have been shown to activate the adenylate cyclase gene and
lead to constitutive cAMP signaling. Several preliminary reports have suggested a role for …

Hematologic values were analyzed for 44 people who were 84 years of age or older.
Individuals were selected based on extensive long-term records confirming their excellent …

Objective.—To assess the efficacy of oral iron therapy in the recovery of patients'
hemoglobin levels after major surgery. Design.—Randomized controlled trial. Setting …