Malignant progression of anal intra‐epithelial neoplasia

AJM Watson, BB Smith, MR Whitehead… - ANZ journal of …, 2006 - Wiley Online Library
Background: Anal intra‐epithelial neoplasia (AIN) is believed to be a precursor to squamous
cell carcinoma of the anus. The risk of developing anal cancer in patients with AIN, although …

Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer

K Chitcholtan, E Asselin, S Parent, PH Sykes… - Experimental cell …, 2013 - Elsevier
Abstract Three-dimensional (3D) in vitro models have an invaluable role in understanding
the behaviour of tumour cells in a well defined microenvironment. This is because some …

[HTML][HTML] The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer

K Chitcholtan, PH Sykes, JJ Evans - Journal of translational medicine, 2012 - Springer
Background Advanced endometrial cancer often shows resistance to clinical chemotherapy
although potencies of anticancer drugs in vitro are promising. The disparity suggests that in …

Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer

C Kuiper, IGM Molenaar, GU Dachs, MJ Currie… - Cancer research, 2010 - AACR
Activation of the transcription factor hypoxia-inducible factor (HIF)-1 allows solid tumors to
thrive under conditions of metabolic stress. Because HIF-1 is switched off by hydroxylation …

Exploring international differences in ovarian cancer treatment: a comparison of clinical practice guidelines and patterns of care

CH Norell, J Butler, R Farrell, A Altman… - International Journal of …, 2020 - ijgc.bmj.com
Introduction The International Cancer Benchmarking Partnership demonstrated international
differences in ovarian cancer survival, particularly for women aged 65–74 with advanced …

[HTML][HTML] Tumour initiation: a discussion on evidence for a “load-trigger” mechanism

JJ Evans, MM Alkaisi, PH Sykes - Cell Biochemistry and Biophysics, 2019 - Springer
Appropriate mechanical forces on cells are vital for normal cell behaviour and this review
discusses the possibility that tumour initiation depends partly on the disruption of the normal …

[HTML][HTML] Gene and protein expression signature of endometrial glandular and stromal compartments during the window of implantation

GE Evans, JA Martínez-Conejero, GTM Phillipson… - Fertility and sterility, 2012 - Elsevier
OBJECTIVE: To map the changes in messenger RNA (mRNA) and protein abundance
during the window of implantation in specifically endometrial stromal and glandular …

[HTML][HTML] Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-κB protein

AB Tino, K Chitcholtan, PH Sykes, A Garrill - Journal of ovarian research, 2016 - Springer
Background Key features of advanced ovarian cancer include metastasis via cell clusters in
the abdominal cavity and increased chemoresistance. Resveratrol and derivatives of …

[HTML][HTML] Resveratrol, acetyl-resveratrol, and polydatin exhibit antigrowth activity against 3D cell aggregates of the SKOV-3 and OVCAR-8 ovarian cancer cell lines

SJ Hogg, K Chitcholtan, W Hassan, PH Sykes… - Obstetrics and …, 2015 - hindawi.com
Resveratrol has aroused significant scientific interest as it has been claimed that it exhibits a
spectrum of health benefits. These include effects as an anti-inflammatory and an antitumour …

Predicting regression of cervical intraepithelial neoplasia grade 2 in women under 25 years

PH Sykes, BJ Simcock, CR Innes, D Harker… - American Journal of …, 2022 - Elsevier
Background A number of retrospective and prospective studies have documented
substantial rates of regression in cervical intraepithelial neoplasia grade 2 lesions in young …