Colon cancer is a common disease that can be sporadic, familial, or inherited. Recent
advances have contributed to the understanding of the molecular basis of these various …

The 4th Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup was
held in Vancouver, Canada, in June 2010. Representatives of 23 cooperative research …

The greater affinity of electrophiles for thiol groups than for hydroxyl or amine groups
provides a teleological basis for the evolution of this mechanism to assist in the maintenance …

Purpose Pazopanib is an oral, multikinase inhibitor of vascular endothelial growth factor
receptor (VEGFR)-1/-2/-3, platelet-derived growth factor receptor (PDGFR)-α/-β, and c-Kit …

PURPOSE: To determine the maximum tolerated dose (MTD) of pemetrexed and carboplatin
given in combination, to derive a recommended dose for phase II studies, and to explore its …

Objective To evaluate the association between surgical timing and postoperative residual
disease status on the efficacy of niraparib first-line maintenance therapy in patients with …

6050 Background: Niraparib is approved at a fixed starting dose (FSD) of 300 mg QD for
maintenance treatment of patients (pts) with recurrent ovarian cancer (OC) achieving a …

Introduction: Extrapulmonary small-cell carcinoma (EPSCC) is a rare disease. Management
is based on small-cell lung carcinoma. Prophylactic cranial irradiation (PCI) is not routinely …

Ignace Vergote, MD, PhD,* Eric Pujade-Lauraine, MD,* Sandro Pignata, MD,* Gunnar B.
Kristensen, MD,* Jonathan Ledermann, MD,* Antonio Casado, MD,* Jalid Sehouli, MD …

Background Analysis of progression-free survival (PFS) as the primary endpoint in
advanced epithelial ovarian, fallopian tube, and primary peritoneal cancer (AEOC) trials may …