Abstract The Signal Transducer and Activator of Transcription (STAT) family of proteins
consists of transcription factors that play a complex and essential role in the regulation of …

Abstract Introduction The Fibroblast Growth Factor Receptor (FGFR) family consists of
Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently …

Reactive oxygen species (ROS) have been implicated in the pathophysiology of a large
number of diseases, and can be harmful due to their high reactivity and deleterious effects …

Purpose Cross-talk between the estrogen receptor (ER) and the phosphoinositide-3-kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) pathways is a mechanism of resistance …

Abstract Interleukin‐6 (IL‐6) is a multifunctional cytokine produced by macrophages, T cells,
B cells, endothelial cells and tumour cells. Interleukin‐6 is able to promote tumour growth by …

Purpose: The prognostic significance of serum interleukin (IL)-8 was evaluated in patients
with metastatic breast cancer. The predictive value of serum IL-8 for the presence of occult …

Antibodies targeting PD-1 or its ligand 1 PD-L1 such as atezolizumab, have great efficacy in
a proportion of metastatic urothelial cancers,. Biomarkers may facilitate identification of these …

Objective. This study was aimed at comparison of neoadjuvant chemotherapy with primary
debulking surgery in advanced ovarian carcinoma. Methods. Retrospective analysis of 285 …

Plasma levels of D-dimer are elevated in cancer patients. Activation of the extrinsic
coagulation system and the fibrinolytic cascade within a tumour is thought to be related with …

Purpose: Inflammatory breast cancer is a distinct and aggressive form of locally advanced
breast cancer with unique clinical and pathological features. Recently, histologic evidence of …