Advances in proximal fluid proteomics for disease biomarker discovery

P Teng, NW Bateman, BL Hood… - Journal of proteome …, 2010 - ACS Publications
Although serum/plasma has been the preferred source for identification of disease
biomarkers, these efforts have been met with little success, in large part due the relatively …

Multiplexed MS/MS for improved data-independent acquisition

JD Egertson, A Kuehn, GE Merrihew, NW Bateman… - Nature …, 2013 - nature.com
In mass spectrometry–based proteomics, data-independent acquisition (DIA) strategies can
acquire a single data set useful for both identification and quantification of detectable …

The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer

DW Garsed, A Pandey, S Fereday, CJ Kennedy… - Nature …, 2022 - nature.com
Fewer than half of all patients with advanced-stage high-grade serous ovarian cancers
(HGSCs) survive more than five years after diagnosis, but those who have an exceptionally …

Factors associated with survival disparities between non-Hispanic Black and White patients with uterine cancer

CW Kucera, C Tian, CM Tarney, C Presti… - JAMA network …, 2023 - jamanetwork.com
Importance Disparities in survival exist between non-Hispanic Black (hereafter, Black) and
non-Hispanic White (hereafter, White) patients with uterine cancer. Objective To investigate …

Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer

NL Burdett, MO Willis, K Alsop, AL Hunt, A Pandey… - Nature …, 2023 - nature.com
High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous
recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to …

[HTML][HTML] Maximizing peptide identification events in proteomic workflows using data-dependent acquisition (DDA)

NW Bateman, SP Goulding, NJ Shulman… - Molecular & Cellular …, 2014 - ASBMB
Current analytical strategies for collecting proteomic data using data-dependent acquisition
(DDA) are limited by the low analytical reproducibility of the method. Proteomic discovery …

[HTML][HTML] Mitochondrial respiration-an important therapeutic target in melanoma

M Barbi de Moura, G Vincent, SL Fayewicz… - 2012 - journals.plos.org
The importance of mitochondria as oxygen sensors as well as producers of ATP and
reactive oxygen species (ROS) has recently become a focal point of cancer research …

Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical …

P Teng, NW Bateman, KM Darcy, CA Hamilton… - Gynecologic …, 2015 - Elsevier
Objective Significant reductions in gynecologic (GYN) cancer mortality and morbidity require
treatments that prevent and reverse resistance to chemotherapy and radiation. The objective …

[PDF][PDF] Molecular analysis of clinically defined subsets of high-grade serous ovarian cancer

S Lee, L Zhao, C Rojas, NW Bateman, H Yao, OD Lara… - Cell reports, 2020 - cell.com
The diversity and heterogeneity within high-grade serous ovarian cancer (HGSC), which is
the most lethal gynecologic malignancy, is not well understood. Here, we perform …

[HTML][HTML] Intestinal tumor progression is associated with altered function of KLF5

NW Bateman, D Tan, RG Pestell, JD Black… - Journal of Biological …, 2004 - ASBMB
Krüppel-like transcription factors have been linked to cell growth regulation and
tumorigenesis in a number of systems. In the intestinal epithelium, expression of KLF5 …