Complications of pelvic radiation in patients treated for gynecologic malignancies

AN Viswanathan, LJ Lee, JR Eswara, NS Horowitz… - Cancer, 2014 - Wiley Online Library
Radiation therapy is a critical treatment modality in the management of patients with
gynecologic tumors. New highly conformal external‐beam and brachytherapy techniques …

Placental site trophoblastic tumors and epithelioid trophoblastic tumors: Biology, natural history, and treatment modalities

NS Horowitz, DP Goldstein, RS Berkowitz - Gynecologic oncology, 2017 - Elsevier
Placental site (PSTT) and epithelioid trophoblastic tumor (ETT) are rare types of gestational
trophoblastic neoplasia (GTN) that arise from intermediate trophoblast. Given that this cell of …

[PDF][PDF] Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy

J Montero, KA Sarosiek, JD DeAngelo, O Maertens… - Cell, 2015 - cell.com
There is a lack of effective predictive biomarkers to precisely assign optimal therapy to
cancer patients. While most efforts are directed at inferring drug response phenotype based …

Prediction of DNA repair inhibitor response in short-term patient-derived ovarian cancer organoids

SJ Hill, B Decker, EA Roberts, NS Horowitz, MG Muto… - Cancer discovery, 2018 - AACR
Based on genomic analysis, 50% of high-grade serous ovarian cancers (HGSC) are
predicted to have DNA repair defects. Whether this substantial subset of HGSCs actually …

Impact of obesity on chemotherapy management and outcomes in women with gynecologic malignancies

NS Horowitz, AA Wright - Gynecologic oncology, 2015 - Elsevier
Objective To describe the effects of obesity on the pharmacokinetics and dosing of
chemotherapies and provide recommendations for chemotherapy management in obese …

Does aggressive surgery improve outcomes? Interaction between preoperative disease burden and complex surgery in patients with advanced-stage ovarian cancer …

NS Horowitz, A Miller, B Rungruang… - Obstetrical & …, 2015 - journals.lww.com
Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and
5-year survival is low. Initial management includes primary debulking surgery (PDS) …

Tumor size, depth of invasion, and histologic grade as prognostic factors of lymph node involvement in endometrial cancer: a SEER analysis

R Vargas, JA Rauh-Hain, J Clemmer, RM Clark… - Gynecologic …, 2014 - Elsevier
Objectives The objective of this investigation was to evaluate the risk of nodal metastasis in
patients with endometrial cancer, using the Mayo criteria, in a population-based analysis …

Platinum resistance after neoadjuvant chemotherapy compared to primary surgery in patients with advanced epithelial ovarian carcinoma

JA Rauh-Hain, CC Nitschmann, MJ Worley Jr… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: Primary debulking surgery (PDS) has historically been the standard treatment
for advanced ovarian cancer. Recent data appear to support a paradigm shift toward …

Prospective evaluation of FDG-PET for detecting pelvic and para-aortic lymph node metastasis in uterine corpus cancer

NS Horowitz, F Dehdashti, TJ Herzog, JS Rader… - Gynecologic …, 2004 - Elsevier
OBJECTIVES: To estimate the sensitivity and specificity of positron emission tomography
(PET) with 2-[18F] fluoro-2-deoxy-d-glucose (FDG) for detecting pelvic and para-aortic lymph …

Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer?

DE Cohn, NS Horowitz, DG Mutch, SM Kim… - Gynecologic …, 2002 - Elsevier
Objective. Thegoal of this study was to determine the influence of LVSI (lymphvascular
space involvement) on the risk of lymph node metastases from endometrial cancer …