Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints

…, A Yeramian, M Santacana, N Eritja… - Journal of clinical …, 2009 - jcp.bmj.com
This article reviews the main molecular alterations involved in endometrial carcinoma. Five
molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and …

Autophagy in the physiological endometrium and cancer

L Devis-Jauregui, N Eritja, ML Davis, X Matias-Guiu… - Autophagy, 2021 - Taylor & Francis
Autophagy is a highly conserved catabolic process and a major cellular pathway for the
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …

Endometrial carcinoma: specific targeted pathways

N Eritja, A Yeramian, BJ Chen, D Llobet-Navas… - Molecular Genetics of …, 2017 - Springer
Endometrial cancer (EC) is the most common gynecologic malignancy in the western world
with more than 280,000 cases per year worldwide. Prognosis for EC at early stages, when …

Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer

N Eritja, BJ Chen, R Rodríguez-Barrueco… - Autophagy, 2017 - Taylor & Francis
Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in
complete tumor remission and are frequently challenged by the appearance of refractory cell …

[HTML][HTML] Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma

J Pallarés, A Velasco, N Eritja, M Santacana… - Modern …, 2008 - nature.com
Alterations in the regulation of the RAS–MAPK pathway are frequent in endometrial
carcinoma. RASSF1A is a tumor-suppressor gene that can regulate this pathway negatively …

[HTML][HTML] A novel three-dimensional culture system of polarized epithelial cells to study endometrial carcinogenesis

N Eritja, D Llobet, M Domingo, M Santacana… - The American journal of …, 2010 - Elsevier
Development of three-dimensional (3D) cultures that mimic in vivo tissue organization has a
pivotal role in the investigation of the involvement of cell adhesion and polarity genes in the …

An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias

C Mirantes, N Eritja, MA Dosil… - Disease models & …, 2013 - journals.biologists.com
SUMMARY PTEN is one of the most frequently mutated tumor suppressor genes in human
cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse …

Antioxidants block proteasome inhibitor function in endometrial carcinoma cells

D Llobet, N Eritja, M Encinas, A Sorolla… - Anti-cancer …, 2008 - journals.lww.com
We have recently demonstrated that proteasome inhibitors can be effective in inducing
apoptotic cell death in endometrial carcinoma cell lines and primary culture explants …

CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells

D Llobet, N Eritja, M Encinas, N Llecha, A Yeramian… - Oncogene, 2008 - nature.com
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a
promising antineoplastic agent because of its ability to selectively kill tumoral cells …

The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms

D Llobet, N Eritja, A Yeramian, J Pallares… - European Journal of …, 2010 - Elsevier
Sorafenib induces apoptosis and enhances Tumour Necrosis Factor-Related Apoptosis-
Inducing Ligand (TRAIL)-induced cell killing of tumoural cells. We have investigated the …