Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints
…, A Yeramian, M Santacana, N Eritja… - Journal of clinical …, 2009 - jcp.bmj.com
This article reviews the main molecular alterations involved in endometrial carcinoma. Five
molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and …
molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and …
Autophagy in the physiological endometrium and cancer
L Devis-Jauregui, N Eritja, ML Davis, X Matias-Guiu… - Autophagy, 2021 - Taylor & Francis
Autophagy is a highly conserved catabolic process and a major cellular pathway for the
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …
Endometrial carcinoma: specific targeted pathways
N Eritja, A Yeramian, BJ Chen, D Llobet-Navas… - Molecular Genetics of …, 2017 - Springer
Endometrial cancer (EC) is the most common gynecologic malignancy in the western world
with more than 280,000 cases per year worldwide. Prognosis for EC at early stages, when …
with more than 280,000 cases per year worldwide. Prognosis for EC at early stages, when …
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer
N Eritja, BJ Chen, R Rodríguez-Barrueco… - Autophagy, 2017 - Taylor & Francis
Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in
complete tumor remission and are frequently challenged by the appearance of refractory cell …
complete tumor remission and are frequently challenged by the appearance of refractory cell …
[HTML][HTML] Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma
J Pallarés, A Velasco, N Eritja, M Santacana… - Modern …, 2008 - nature.com
Alterations in the regulation of the RAS–MAPK pathway are frequent in endometrial
carcinoma. RASSF1A is a tumor-suppressor gene that can regulate this pathway negatively …
carcinoma. RASSF1A is a tumor-suppressor gene that can regulate this pathway negatively …
[HTML][HTML] A novel three-dimensional culture system of polarized epithelial cells to study endometrial carcinogenesis
N Eritja, D Llobet, M Domingo, M Santacana… - The American journal of …, 2010 - Elsevier
Development of three-dimensional (3D) cultures that mimic in vivo tissue organization has a
pivotal role in the investigation of the involvement of cell adhesion and polarity genes in the …
pivotal role in the investigation of the involvement of cell adhesion and polarity genes in the …
An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
C Mirantes, N Eritja, MA Dosil… - Disease models & …, 2013 - journals.biologists.com
SUMMARY PTEN is one of the most frequently mutated tumor suppressor genes in human
cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse …
cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse …
Antioxidants block proteasome inhibitor function in endometrial carcinoma cells
We have recently demonstrated that proteasome inhibitors can be effective in inducing
apoptotic cell death in endometrial carcinoma cell lines and primary culture explants …
apoptotic cell death in endometrial carcinoma cell lines and primary culture explants …
CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a
promising antineoplastic agent because of its ability to selectively kill tumoral cells …
promising antineoplastic agent because of its ability to selectively kill tumoral cells …
The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms
D Llobet, N Eritja, A Yeramian, J Pallares… - European Journal of …, 2010 - Elsevier
Sorafenib induces apoptosis and enhances Tumour Necrosis Factor-Related Apoptosis-
Inducing Ligand (TRAIL)-induced cell killing of tumoural cells. We have investigated the …
Inducing Ligand (TRAIL)-induced cell killing of tumoural cells. We have investigated the …