Abstract Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical
regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of dysregulated lipid
and glucose metabolism, which is often associated with obesity, dyslipidemia and insulin …

Because undesirable pharmacokinetics and toxicity of candidate compounds are the main
reasons for the failure of drug development, it has been widely recognized that absorption …

Objectives Studies reported associations of inflammatory markers with the severity of COVID-
19, but conclusions were inconsistent. We aimed to provide an overview of the association …

ABSTRACT Coronavirus disease 2019 (COVID-19), caused by infection with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. This …

Tumours use various strategies to evade immune surveillance,. Immunotherapies targeting
tumour immune evasion such as immune checkpoint blockade have shown considerable …

Using meta-analysis to explore clinical determinants for death of COVID-19 patients has
been a problem due to insufficient sample size and overlapped cases [1]. In the study, we re …

Gut microbiota plays a critical role in the maintenance of host health. As a low-cost and
genetically tractable vertebrate model, zebrafish have been widely used for biological …

Tumor-associated macrophages (TAMs) can influence ovarian cancer growth, migration,
and metastasis, but the detailed mechanisms underlying ovarian cancer metastasis remain …

Pregnant women may be at higher risk of severe complications associated with the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical …