Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor
Extracellular glycosylation is a critical determinant of malignant character. Here, we report
that N-acetylgalactosaminyltransferase 2 (GALNT2), the enzyme that mediates the initial …
that N-acetylgalactosaminyltransferase 2 (GALNT2), the enzyme that mediates the initial …
GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity
MC Lin, MJ Huang, CH Liu, TL Yang, MC Huang - Oral oncology, 2014 - Elsevier
Objectives Oral squamous cell carcinoma (OSCC) is one of the leading cancers worldwide.
Aberrant glycosylation affects many cellular properties in cancers, including OSCC. This …
Aberrant glycosylation affects many cellular properties in cancers, including OSCC. This …
C1GALT1 enhances proliferation of hepatocellular carcinoma cells via modulating MET glycosylation and dimerization
YM Wu, CH Liu, MJ Huang, HS Lai, PH Lee, RH Hu… - Cancer research, 2013 - AACR
Altered glycosylation is a hallmark of cancer. The core 1 β1, 3-galactosyltransferase
(C1GALT1) controls the formation of mucin-type O-glycans, far overlooked and …
(C1GALT1) controls the formation of mucin-type O-glycans, far overlooked and …
[HTML][HTML] β1, 4-N-acetylgalactosaminyltransferase III modulates cancer stemness through EGFR signaling pathway in colon cancer cells
MI Che, J Huang, JS Hung, YC Lin, MJ Huang, HS Lai… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Cancer stem cells are cancer cells characterized with tumor initiating capacity. β1, 4-N-
acetylgalactosaminyltransferase III (B4GALNT3) synthesizes GalNAcβ1-4GlcNAc …
acetylgalactosaminyltransferase III (B4GALNT3) synthesizes GalNAcβ1-4GlcNAc …
[HTML][HTML] C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2
Abstract Core 1 β1, 3-galactosyltransferase (C1GALT1) transfers galactose (Gal) to N-
acetylgalactosamine (GalNAc) to form Galβ1, 3GalNAc (T antigen). Aberrant O-glycans …
acetylgalactosamine (GalNAc) to form Galβ1, 3GalNAc (T antigen). Aberrant O-glycans …
[HTML][HTML] Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway
Aberrant glycosylation is frequently observed in cancers. Core 1 β1, 3-galactosyltransferase
(C1GALT1) is an exclusive enzyme in humans that catalyzes the biosynthesis of core 1 O …
(C1GALT1) is an exclusive enzyme in humans that catalyzes the biosynthesis of core 1 O …
[HTML][HTML] Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling
O-glycosylation is a common protein modification. Aberrant O-glycosylation is associated
with many cancers. GALNT1 is a GalNAc-transferase that initiates protein O-glycosylation …
with many cancers. GALNT1 is a GalNAc-transferase that initiates protein O-glycosylation …
β-1, 4-Galactosyltransferase III enhances invasive phenotypes via β1-integrin and predicts poor prognosis in neuroblastoma
HH Chang, CH Chen, CH Chou, YF Liao, MJ Huang… - Clinical cancer …, 2013 - AACR
Purpose: Neuroblastoma (NB) is a neural crest-derived tumor that commonly occurs in
childhood. β-1, 4-Galactosyltransferase III (B4GALT3) is highly expressed in human fetal …
childhood. β-1, 4-Galactosyltransferase III (B4GALT3) is highly expressed in human fetal …
[HTML][HTML] C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin β1 glycosylation and activity
CH Liu, RH Hu, MJ Huang, IR Lai, CH Chen, HS Lai… - PloS one, 2014 - journals.plos.org
Cancer cell invasion and metastasis are the primary causes of treatment failure and death in
hepatocellular carcinoma (HCC). We previously reported that core 1 β1, 3 …
hepatocellular carcinoma (HCC). We previously reported that core 1 β1, 3 …
MUC20 promotes aggressive phenotypes of epithelial ovarian cancer cells via activation of the integrin β1 pathway
CH Chen, MK Shyu, SW Wang, CH Chou… - Gynecologic …, 2016 - Elsevier
Objective Mucin (MUC) 20 has recently been implicated to play a role in human
carcinogenesis. However, the role of MUC20 in epithelial ovarian cancer (EOC) remains to …
carcinogenesis. However, the role of MUC20 in epithelial ovarian cancer (EOC) remains to …