Breast cancer (BC) is the most frequent carcinoma in women. The cumulative risk for the
disease is 10% up to the age of 80 years. A familial history of BC and ovarian cancer (OC) is …

Thyroid disorders have a great impact on fertility in both sexes. Hyperthyroidism and
hypothyroidism cause changes in sex hormone-binding globulin (SHBG), prolactin …

Research involving estrogen and progesterone receptors (ER and PR) have greatly
contributed to our understanding of cell signaling and transcriptional regulation. In addition …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in
cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic …

Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …

Context The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone
receptor–positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and …

Purpose Recent advances in DNA sequencing have led to the development of breast cancer
susceptibility gene panels for germline genetic testing of patients. We assessed the …