High glucose levels enhance platelet activation: involvement of multiple mechanisms

D Sudic, M Razmara, M Forslund, Q Ji… - British journal of …, 2006 - Wiley Online Library
Diabetes mellitus (DM) and hyperglycaemia are associated with platelet activation. The
present study was designed to investigate how high glucose levels influence platelet …

[HTML][HTML] Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR …

M Razmara, CH Heldin, J Lennartsson - Cell Communication and …, 2013 - Springer
Mammalian target of rapamycin (mTOR) can be found in two multi-protein complexes, ie
mTORC1 (containing Raptor) and mTORC2 (containing Rictor). Here, we investigated the …

[HTML][HTML] Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

C Kolliopoulos, E Raja, M Razmara, P Heldin… - Journal of Biological …, 2019 - ASBMB
TGFβ signaling via SMAD proteins and protein kinase pathways up-or down-regulates the
expression of many genes and thus affects physiological processes, such as differentiation …

[HTML][HTML] MiR-486-3p was downregulated at microRNA profiling of adrenals of multiple endocrine neoplasia type 1 mice, and inhibited human adrenocortical …

SC Li, A Monazzam, M Razmara, X Chu, P Stålberg… - Scientific Reports, 2021 - nature.com
Adrenocortical carcinoma is a rare aggressive disease commonly recurring regardless of
radical surgery. Although data on genomic alterations in malignant tumors are accumulating …

MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis

M Razmara, G Eger, C Rorsman, CH Heldin… - Cellular signalling, 2012 - Elsevier
MAP kinase phosphatase-3 (MKP3), also known as DUSP6 or Pyst1, is a dual specificity
phosphatase considered to selectively dephosphorylate extracellular-signal-regulated …

[HTML][HTML] Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration

M Razmara, A Monazzam, B Skogseid - Cell Communication and …, 2018 - Springer
Background Mammalian target of rapamycin (mTOR) is a master regulator of various cellular
responses by forming two functional complexes, mTORC1 and mTORC2. mTOR signaling is …

[HTML][HTML] Generation and characterization of CRISPR/Cas9-mediated MEN1 knockout BON1 cells: a human pancreatic neuroendocrine cell line

A Monazzam, SC Li, H Wargelius, M Razmara… - Scientific Reports, 2020 - nature.com
Among patients with the rare diagnosis of pancreatic neuroendocrine tumor (P-NET), a
substantial proportion suffer from the inherited cancer syndrome multiple endocrine …

[PDF][PDF] Food Intake Enhances Thromboxane Receptor–Mediated Platelet Activation in Type 2 Diabetic Patients but Not in Healthy Subjects

M Razmara, P Hjemdahl, M Yngen, CG Östenson… - Diabetes …, 2007 - researchgate.net
METHODS—Fifteen patients with fairly well-controlled type 2 diabetes (mean SE age 53 6
years, 11 male and 4 female, BMI 28.1 3.8 kg/m2, A1C 6.8 1.7%[reference 5.2%]). The study …

[HTML][HTML] Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 /PET

A Monazzam, J Lau, I Velikyan, SC Li, M Razmara… - Scientific Reports, 2018 - nature.com
Multiple endocrine neoplasia type 1 (MEN1) is an endocrine tumor syndrome caused by
heterozygous mutations in the MEN1 tumor suppressor gene. The MEN1 pancreas of the …

[PDF][PDF] MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53–a Nordic Lymphoma Group …

JM Rodrigues, P Hollander, L Schmidt, E Gkika… - …, 2023 - haematologica.org
The transcription factor MYC is a well-described oncogene with an important role in
lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) …