S ociety of G ynecologic O ncology recommendations for the prevention of ovarian cancer

JL Walker, CB Powell, L Chen, J Carter, VL Bae Jump… - Cancer, 2015 - Wiley Online Library
Mortality from ovarian cancer may be dramatically reduced with the implementation of
attainable prevention strategies. The new understanding of the cells of origin and the …

[PDF][PDF] SATB1 expression governs epigenetic repression of PD-1 in tumor-reactive T cells

TL Stephen, KK Payne, RA Chaurio, MJ Allegrezza… - Immunity, 2017 - cell.com
Despite the importance of programmed cell death-1 (PD-1) in inhibiting T cell effector
activity, the mechanisms regulating its expression remain poorly defined. We found that the …

[PDF][PDF] Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression

TL Stephen, MR Rutkowski, MJ Allegrezza… - Immunity, 2014 - cell.com
Tumor-reactive T cells become unresponsive in advanced tumors. Here we have
characterized a common mechanism of T cell unresponsiveness in cancer driven by the …

NAMPT inhibition suppresses cancer stem-like cells associated with therapy-induced senescence in ovarian cancer

T Nacarelli, T Fukumoto, JA Zundell, N Fatkhutdinov… - Cancer research, 2020 - AACR
Epithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The
standard-of-care treatment for EOC is platinum-based chemotherapy such as cisplatin …

[PDF][PDF] Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells

AJ Tesone, MR Rutkowski, E Brencicova, N Svoronos… - Cell reports, 2016 - cell.com
Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional
programs. Using a conditional knockout mouse, we find that Satb1 is required for normal …

[PDF][PDF] EZH2 inhibition sensitizes CARM1-high, homologous recombination proficient ovarian cancers to PARP inhibition

S Karakashev, T Fukumoto, B Zhao, J Lin, S Wu… - Cancer Cell, 2020 - cell.com
In response to DNA double-strand breaks, MAD2L2-containing shieldin complex plays a
critical role in the choice between homologous recombination (HR) and non-homologous …

[HTML][HTML] ARID1A promotes genomic stability through protecting telomere cohesion

B Zhao, J Lin, L Rong, S Wu, Z Deng… - Nature …, 2019 - nature.com
ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A
mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A …

[HTML][HTML] CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer

B Singha, SL Harper, AR Goldman, BG Bitler… - Scientific reports, 2018 - nature.com
New plasma and tissue biomarkers of epithelial ovarian cancer (EOC) could improve early
diagnosis and post-diagnosis clinical management. Here we investigated tissue staining …

Morcellation and the incidence of occult uterine malignancy: a dual-institution review

TM Picerno, MN Wasson, ARG Rios… - International Journal of …, 2016 - ijgc.bmj.com
Objectives To determine the incidence of unsuspected uterine sarcoma (UtSarc), other
uterine malignancies, and potential malignancies at the time of hysterectomy or …

Intraperitoneal chemotherapy in a pregnant woman with ovarian cancer

ER Smith, ME Borowsky, VD Jain - Obstetrics & Gynecology, 2013 - journals.lww.com
BACKGROUND: Ovarian cancer diagnosed in pregnancy is rare. There is limited evidence
to guide the choice of optimal chemotherapeutic management for treatment of disease …