Kinetics of heme interaction with heme-binding proteins: the effect of heme aggregation state

K Kuželová, M Mrhalová, Z Hrkal - Biochimica et Biophysica Acta (BBA) …, 1997 - Elsevier
The kinetics of the interaction of heme with hemopexin and albumin was monitored by
measuring the time dependence of changes in the Soret absorption spectra. Since the …

[HTML][HTML] Breast cancer: role of polymorphisms in biotransformation enzymes

J Šarmanová, S Šůsová, I Gut, M Mrhalová… - European journal of …, 2004 - nature.com
We aimed at determining whether any association exists between genetic polymorphisms in
epoxide hydrolase (EPHX1), NADPH-quinone oxidoreductase (NQO1), glutathione S …

Molecular and immunohistochemical analyses of BCL2, KI-67, and cyclin D1 expression in synovial sarcoma

L Krsková, M Kalinová, H Břízová, M Mrhalová… - Cancer Genetics and …, 2009 - Elsevier
Synovial sarcoma (SS) is a highly aggressive soft tissue sarcoma that causes death in more
than half of the affected patients. An immunohistochemical and molecular study of the BCL2 …

[PDF][PDF] A whole population study of gastrointestinal stromal tumors in the Czech Republic and Slovakia

P Brabec, J Sufliarsky, Z Linke, L Plank, M Mrhalová… - Neoplasma, 2009 - researchgate.net
Locations other than the small intestine and stomach had significantly higher contribution of
high-risk tumors. The median time of overall survival was 93.2 months, 5-year relative …

Mantle cell lymphoma: improved diagnostics using a combined approach of immunohistochemistry and identification of t (11; 14)(q13; q32) by polymerase chain …

R Kodet, M Mrhalová, L Krsková, J Soukup, V Campr… - Virchows Archiv, 2003 - Springer
Introduction Mantle cell lymphoma (MCL) is a clinicopathological entity characterized by an
aggressive clinical course, morphological features, and overexpression of cyclin D1 due to …

Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype

P Holý, V Hlaváč, P Ostašov, V Brynychová… - Biochimie, 2022 - Elsevier
Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies,
including cancer. In breast cancer, the link is especially strong due to interactions between …

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer

P Holý, V Brynychová, K Šeborová… - Molecular …, 2023 - Wiley Online Library
Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective
estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear …

Targeted DNA sequencing of high‐grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene …

P Holý, V Hlaváč, K Šeborová, S Šůsová… - … Journal of Cancer, 2024 - Wiley Online Library
High‐grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian
cancer and is among the most fatal gynecological malignancies worldwide, due to late …

[PDF][PDF] Determination of biological behavior of solitary fibrous tumors: Correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion …

L Krskova, I Odintsov, O Fabián, P Hroudova… - Neoplasma, 2022 - researchgate.net
We present a retrospective study of 65 cases of solitary fibrous tumors (SFTs) of several
localizations including the most common site of origin in the pleura and lungs. SFTs are …

Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy

V Hlaváč, P Holý, R Václavíková, L Rob… - Life Science …, 2022 - life-science-alliance.org
Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy
and recurrence. We performed whole-exome sequencing of blood and tumor tissue pairs of …