Introduction Cowden syndrome is a cancer predisposition syndrome caused by pathogenic
variants in PTEN. The affected patients possess an increased risk of breast, thyroid, renal …

Introduction: Vascular endothelial growth factors (VEGFs) play a central role in angiogenesis
and consequently, in various steps of ovarian carcinogenesis. Gene polymorphisms within …

Background It is well known that the vascular endothelial growth factor (VEGF) system is
essential to the growth of tumors, but its possible changes during tumor development are still …

Introduction Sertoli–Leydig cell tumors are rare tumors of the ovary. Moderate and poorly
differentiated tumors can metastasize and have a poor outcome. A pathogenic variant in …

Purpose Treatment of multi-resistant epithelial ovarian cancer represents a clinical
challenge with limited choices. Anti-angiogenic therapy has shown great potential in …