Genomic and epigenomic aberrations in esophageal squamous cell carcinoma and implications for patients

DC Lin, MR Wang, HP Koeffler - Gastroenterology, 2018 - Elsevier
Esophageal squamous cell carcinoma (ESCC) is a common malignancy without effective
therapy. The exomes of more than 600 ESCCs have been sequenced in the past 4 years …

Advances in cryopreservation of in vitro-derived propagules: Technologies and explant sources

MR Wang, M Lambardi, F Engelmann… - Plant Cell, Tissue and …, 2021 - Springer
Genetic improvements in plant breeding are dependent upon having access to novel plant
genetic resources that are available in plant genebanks. Many crops that are vegetatively …

[HTML][HTML] ROS-induced oxidative stress in plant cryopreservation: Occurrence and alleviation

L Ren, MR Wang, QC Wang - Planta, 2021 - Springer
Main conclusion Reactive oxygen species (ROS)-induced oxidative stress results in low
success or even total failure of cryopreservation. Better understanding of how the plant …

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Q Sun, X Chen, J Ma, H Peng, F Wang… - Proceedings of the …, 2011 - National Acad Sciences
Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions,
including when, how, and why cancer cells become highly glycolytic, remain less clear. For …

Genomic and molecular characterization of esophageal squamous cell carcinoma

DC Lin, JJ Hao, Y Nagata, L Xu, L Shang, X Meng… - Nature …, 2014 - nature.com
Esophageal squamous cell carcinoma (ESCC) is prevalent worldwide and particularly
common in certain regions of Asia. Here we report the whole-exome or targeted deep …

[HTML][HTML] Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents

WP Guo, XD Lin, W Wang, JH Tian, ML Cong… - PLoS …, 2013 - journals.plos.org
Hantaviruses are among the most important zoonotic pathogens of humans and the subject
of heightened global attention. Despite the importance of hantaviruses for public health …

Protective effect of green tea on the risks of chronic gastritis and stomach cancer

VW Setiawan, ZF Zhang, GP Yu, QY Lu… - … Journal of Cancer, 2001 - Wiley Online Library
Despite the declining trend, stomach cancer remains the second most common cancer
worldwide. We examined the role of green tea consumption on chronic gastritis and stomach …

Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies

YC Sung, PR Jin, LA Chu, FF Hsu, MR Wang… - Nature …, 2019 - nature.com
Abnormal tumour vasculature has a significant impact on tumour progression and response
to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis …

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma

JJ Hao, DC Lin, HQ Dinh, A Mayakonda, YY Jiang… - Nature …, 2016 - nature.com
Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies,
but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal …

[PDF][PDF] Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

D Wu, J Dou, X Chai, C Bellis, A Wilm, CC Shih… - Cell, 2019 - cell.com
Underrepresentation of Asian genomes has hindered population and medical genetics
research on Asians, leading to population disparities in precision medicine. By whole …