Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW …

…, P Borkowska, M Paul-Samojedny… - Biomedicine & …, 2017 - Elsevier
Polyphenols such as apigenin, kaempferol or resveratrol are typically found in plants,
including fruits, vegetables, herbs and spices, which have a wide range of biological …

Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture

E Obuchowicz, AM Bielecka, M Paul-Samojedny… - Pharmacological …, 2014 - Springer
Background Recent evidence has suggested that antidepressants evoke neuroprotective
and immunomodulatory effects in the brain, partly at least, by inhibiting glia activation. This …

Functional polymorphism in the interleukin-6 and interleukin-10 genes in patients with paranoid schizophrenia—a case-control study

M Paul-Samojedny, M Kowalczyk, R Suchanek… - Journal of molecular …, 2010 - Springer
Schizophrenia is a multifactorial disease with changes in immunological system. Such
changes are the result of cytokine-level disturbances connected with cytokine gene …

[HTML][HTML] Impact of antibiotics on the proliferation and differentiation of human adipose-derived mesenchymal stem cells

…, J Gola, B Sikora, J Hybiak, M Paul-Samojedny… - International Journal of …, 2017 - mdpi.com
Adipose tissue is a promising source of mesenchymal stem cells. Their potential to
differentiate and regenerate other types of tissues may be affected by several factors. This …

[HTML][HTML] Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis

M Paul-Samojedny, D Kokocińska, A Samojedny… - … et Biophysica Acta (BBA …, 2005 - Elsevier
The rate of tumour growth is dependent on the balance between proliferation and apoptosis
at all stages of carcinogenesis. Apoptosis inhibition, in turn, depends partly on the balance …

Association of Interleukin 2 (IL-2), Interleukin 6 (IL-6), and TNF-alpha (TNFα) Gene Polymorphisms With Paranoid Schizophrenia in a Polish Population

M Paul-Samojedny, A Owczarek… - The Journal of …, 2013 - Am Neuropsych Assoc
Numerous reports have brought attention to the potential role of cytokines in schizophrenia.
The aim of the study was to determine whether polymorphisms of IL-2, IL-6, and TNFα genes …

Different influence of antipsychotics on the balance between pro-and anti-inflammatory cytokines depends on glia activation: an in vitro study

…, AM Bielecka-Wajdman, M Paul-Samojedny… - Cytokine, 2017 - Elsevier
The microglial hypothesis of schizophrenia suggests that its neuropathology is closely
associated with neuroinflammation manifested, inter alia, by an increased expression of …

BDNF val66met polymorphism is associated with age at onset and intensity of symptoms of paranoid schizophrenia in a Polish population

…, A Owczarek, M Paul-Samojedny… - The Journal of …, 2013 - Am Neuropsych Assoc
The brain-derived neurotrophic factor (BDNF) is one of the candidate genes for
schizophrenia. There is evidence that val66met polymorphism may be involved in the …

[HTML][HTML] Interleukin-1beta promoter (− 31T/C and− 511C/T) polymorphisms in major recurrent depression

…, K Kucia, S Rzezniczek, M Paul-Samojedny… - Journal of Molecular …, 2011 - Springer
To elucidate a genetic predisposition to major depressive disorder, we investigated two
polymorphisms (− 31T/C and− 511C/T) in the interleukin-1beta promoter region in patients …

[HTML][HTML] Inositol hexaphosphate inhibits proliferation and induces apoptosis of colon cancer cells by suppressing the AKT/mTOR signaling pathway

M Kapral, J Wawszczyk, K Jesse, M Paul-Samojedny… - Molecules, 2017 - mdpi.com
AKT, a serine/threonine protein kinase and mammalian target of rapamycin (mTOR) plays a
critical role in the proliferation and resistance to apoptosis that are essential to the …