Quantifying factors for the success of stratified medicine

MR Trusheim, B Burgess, SX Hu, T Long… - Nature reviews Drug …, 2011 - nature.com
Co-developing a drug with a diagnostic to create a stratified medicine—a therapy that is
targeted to a specific patient population on the basis of a clinical characteristic such as a …

Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non–small-cell lung cancer

AB Sandler, J Nemunaitis, C Denham… - Journal of clinical …, 2000 - ascopubs.org
PURPOSE: The Hoosier Oncology Group has previously reported the results of its phase II
trial of the combination of cisplatin plus gemcitabine. In that study of 27 assessable patients …

Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancer

J Von Pawel, JH Schiller, FA Shepherd… - Journal of Clinical …, 1999 - ascopubs.org
PURPOSE: Topotecan and cyclophosphamide, doxorubicin, and vincristine (CAV) were
evaluated in a randomized, multicenter study of patients with small-cell lung cancer (SCLC) …

Factors influencing the behavior of buried pipelines subjected to earthquake faulting

TH Abdoun, D Ha, MJ O'Rourke, MD Symans… - Soil Dynamics and …, 2009 - Elsevier
Seismic ground faulting is a severe hazard for continuous buried pipelines. Over the years,
researchers have attempted to understand pipe behavior, most frequently via numerical …

Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t (14; 18), 3q27, or other translocations: t (14; 18) and 3q27 are mutually …

AG Bosga-Bouwer, GW van Imhoff… - Blood, The Journal …, 2003 - ashpublications.org
Abstract Chromosomal translocations involving t (14; 18)(q32; q21) and the chromosome
3q27 region are common in B-cell non-Hodgkin lymphoma of germinal center cell origin …

Centrifuge modeling of earthquake effects on buried high-density polyethylene (HDPE) pipelines crossing fault zones

D Ha, TH Abdoun, MJ O'Rourke… - … of geotechnical and …, 2008 - ascelibrary.org
Permanent ground deformation is a severe hazard for continuous buried pipelines. This
technical paper presents results from four centrifuge tests designed to investigate the …

Buried high-density polyethylene pipelines subjected to normal and strike-slip faulting—a centrifuge investigation

D Ha, TH Abdoun, MJ O'Rourke… - Canadian …, 2008 - cdnsciencepub.com
Permanent ground deformation is arguably the most severe hazard for continuous buried
pipelines. This paper presents results from two pairs of centrifuge tests designed to …

Tactile pressure sensors for soil-structure interaction assessment

MC Palmer, TD O'Rourke, NA Olson… - … of geotechnical and …, 2009 - ascelibrary.org
This paper provides an assessment of tactile pressure sensors for geotechnical applications.
A tactile pressure sensor is an array of small sensing units, called sensels, embedded in a …

Earthquake performance of gas transmission pipelines

TD O'Rourke, MC Palmer - Earthquake Spectra, 1996 - journals.sagepub.com
Over 61 years of earthquake performance of steel transmission and distribution supply
pipelines operated by the Southern California Gas Company are reviewed. The seismic …

Numerical modeling of buried HDPE pipelines subjected to normal faulting: a case study

X Xie, MD Symans, MJ O'Rourke… - Earthquake …, 2013 - journals.sagepub.com
A systematic study is presented herein on the seismic response of buried pipelines
subjected to ground fault rupture in the form of normal faulting. In this study, advanced …