Vaginal delivery is the major risk factor for the development of pelvic organ prolapse and
urinary and fecal incontinence, resulting from damage to the pelvic floor muscles, nerves …

Abstract Pelvic Organ Prolapse (POP) is the hidden epidemic. Demographic studies have
shown that women over the age of eighty are the fastest growing population segment in the …

We read with interest the recent original research article by Alarab et al, 1 which examines
the obstetric and perinatal outcome of singleton vaginal breech deliveries at term, as well as …

Purpose In this first edition of the e-book, we present a comprehensive review of the
mechanistic insights centered around the priorities identified during a “think tank” …

Aim: The molecular etiology of pelvic organ prolapse (POP) is complex and not well
understood. We compared the expression/activity of extracellular matrix (ECM)-processing …

Introduction and hypothesis There is clear evidence of the presence of estradiol receptors
(ERs) in the female lower urinary and genital tract. Furthermore, it is a fact that estrogen …

Abstract Introduction and Hypothesis The extracellular matrix proteins collagen and elastin
provide tissue strength and resilience, whereas lysyl oxidase enzymes play a major role in …

Cell-based therapy is a major focus for treatment of stress urinary incontinence (SUI).
However, derivation of primary cells requires tissue biopsies, which often have adverse …

OBJECTIVE: To estimate whether a history of childhood dysfunctional voiding is associated
with urinary incontinence in adulthood. METHODS: Using a case–control study, we …

Objectives To analyze the expression of genes involved in extracellular matrix (ECM)
biogenesis and remodeling in vaginal tissue of women with clinically normal pelvic floor …