The ephemeral nature of most sedimentation processes and the fragmentary character of
the sedimentary record are of first-order importance. Despite a basic uniformity of external …

Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now
survive both their first and subsequent cancers, resulting in a growing number of older …

Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have
been subject to bias, partly through reliance on retrospective studies. We sought to establish …

Purpose Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch
syndrome and result in different but imprecisely known cancer risks. This study aimed to …

Each tumour contains diverse cellular states that underlie intratumour heterogeneity (ITH), a
central challenge of cancer therapeutics. Dozens of recent studies have begun to describe …

The nature of tectonic processes on the early Earth is still controversial. The scarcity of high-
pressure metamorphic rocks such as eclogite (the high-pressure equivalent of basalt) in …

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract
in developed countries. Through genome-wide association studies (GWAS), we have …

BACKGROUND The endometrium is a dynamic, cyclically regenerating tissue: a unique
model of physiological angiogenesis in adults. However, the source of new endothelial cells …

A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the
presence, viral load and integration status of 'high-risk'types of human papillomavirus (HR …

Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …