Aryl hydrocarbon receptor and its diverse ligands and functions: an exposome receptor

L Larigot, L Benoit, M Koual… - Annual Review of …, 2022 - annualreviews.org
The aryl hydrocarbon receptor (AhR) is a transcriptional factor that regulates multiple
functions following its activation by a variety of ligands, including xenobiotics, natural …

[HTML][HTML] Mitochondrial dysfunction as a hallmark of environmental injury

C Duarte-Hospital, A Tête, F Brial, L Benoit, M Koual… - Cells, 2021 - mdpi.com
Environmental factors including diet, sedentary lifestyle and exposure to pollutants largely
influence human health throughout life. Cellular and molecular events triggered by an …

[HTML][HTML] Adverse outcome pathway from activation of the AhR to breast cancer-related death

L Benoit, F Jornod, E Zgheib, C Tomkiewicz… - Environment …, 2022 - Elsevier
Adverse outcome pathways (AOPs) are formalized and structured linear concepts that
connect one molecular initiating event (MIE) to an adverse outcome (AO) via different key …

Pregnancy outcomes in patients with pulmonary arterial hypertension associated with congenital heart disease

M Ladouceur, L Benoit, J Radojevic, A Basquin… - Heart, 2017 - heart.bmj.com
Objective There is growing evidence that maternal mortality in pregnant women with
pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is …

Diagnostic value of indocyanine green fluorescence guided sentinel lymph node biopsy in vulvar cancer: a systematic review

M Koual, L Benoit, HT Nguyen-Xuan, E Bentivegna… - Gynecologic …, 2021 - Elsevier
Introduction Sentinel lymph node biopsy (SLN) helps define lymph node status, a major
prognostic factor in vulvar cancer. The aim of the current systematic review was to assess …

[HTML][HTML] Nomogram predicting the likelihood of parametrial involvement in early-stage cervical cancer: avoiding unjustified radical hysterectomies

L Benoit, V Balaya, B Guani, A Bresset… - Journal of clinical …, 2020 - mdpi.com
Background: We aimed to establish a tool predicting parametrial involvement (PI) in patients
with early-stage cervical cancer and select a sub-group of patients who would most benefit …

[HTML][HTML] A suggested modification to FIGO stage IV epithelial ovarian cancer

M Métairie, L Benoit, M Koual, E Bentivegna, H Wohrer… - Cancers, 2023 - mdpi.com
Simple Summary The identification of prognostic factors is important to improve the
management of patients with ovarian cancer (OC). The staging classification of OC was …

Cigarette smoke and tumor microenvironment copromote aggressiveness of human breast cancer cells

L Benoit, C Tomkiewicz, M Delit, H Khider… - Toxicological …, 2023 - academic.oup.com
Breast cancer is a major public health issue and the role of pollutants in promoting breast
cancer progression has recently been suggested. We aimed to assess if a mixture of …

Parametrial endometriosis: a predictive and prognostic factor for voiding dysfunction and complications

L Benoit, Y Dabi, M Bazot, I Thomassin-Naggara… - European Journal of …, 2022 - Elsevier
Objective Parametrial involvement (PI) in endometriosis is poorly defined resulting in an
underestimation of its impact during surgical excision. The aim of our study was to assess …

How pregnancy impacts adult cyanotic congenital heart disease: a multicenter observational study

M Ladouceur, L Benoit, A Basquin, J Radojevic… - Circulation, 2017 - Am Heart Assoc
Survival into adulthood of patients with unrepaired cyanotic congenital heart defects (CHDs)
is possible when cyanotic CHDs are deemed unsuitable for radical surgical repair but are …