While transport processes for amino acids and glucose have long been known to be
expressed in the luminal and abluminal membranes of the endothelium comprising the …

The role of oxidative stress in the physiopathology of human pregnancy is of particular
interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a …

Cell-to-cell communication happens via diverse mechanisms including the synthesis,
release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles …

Studies completed to date provide persuasive evidence that placental cell-derived
exosomes play a significant role in intercellular communication pathways that potentially …

Vasculogenesis and angiogenesis are critical processes in fetal circulation and placental
vasculature development. Placental mesenchymal stem cells (pMSC) are known to release …

Migration of extravillous trophoblasts (EVT) into decidua and myometrium is a critical
process in the conversion of maternal spiral arterioles and establishing placenta perfusion …

Background/Aim Hypercaloric diet ingestion and sedentary lifestyle result in obesity.
Metabolic syndrome is a cluster of clinical features secondary to obesity, considered as a …

Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

1. Vasodilatation induced by adenosine is mediated through the activation of A2‐
purinoceptors in endothelial and smooth muscle cells. 2. Adenosine induces a rapid and …

Human endothelial dysfunction is a common feature in many diseases of pregnancy, such
as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide …