E6201 [(3S, 4R, 5Z, 8S, 9S, 11E)-14-(ethylamino)-8, 9, 16-trihydroxy-3, 4-dimethyl-3, 4, 9, 19-tetrahydro-1H-2-benzoxacyclotetradecine-1, 7 (8H)-dione], a novel …

M Goto, J Chow, K Muramoto, K Chiba… - … of Pharmacology and …, 2009 - ASPET
The goal of this study is to identify a novel inhibitor with anti-inflammatory and
antiproliferative properties for the treatment of psoriasis. Compound f152A1 [(3 S, 5 Z, 8 S …

[HTML][HTML] Evaluation of circulating tumor DNA in patients with ovarian cancer harboring somatic PIK3CA or KRAS mutations

A Ogasawara, T Hihara, D Shintani… - Cancer Research and …, 2020 - ncbi.nlm.nih.gov
Purpose Circulating tumor DNA (ctDNA) is an attractive source for liquid biopsy to
understand molecular phenotypes of a tumor non-invasively, which is also expected to be …

Discovery of novel and potent retinoic acid receptor α agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives

H Yoshimura, K Kikuchi, S Hibi, K Tagami… - Journal of medicinal …, 2000 - ACS Publications
In the course of our studies on retinoic acid receptor (RAR) agonists, we have designed and
synthesized a series of benzofuran and benzothiophene derivatives. Some of these …

Syntheses and structure− activity relationships of 5, 6, 7, 8-tetrahydro-5, 5, 8, 8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor α agonistic activity

K Kikuchi, S Hibi, H Yoshimura… - Journal of medicinal …, 2000 - ACS Publications
In the course of our studies on retinoic acid receptor (RAR) agonists, we have designed and
synthesized a series of quinoxaline derivatives. One of them, 4-[5-(5, 6, 7, 8-tetrahydro-5, 5 …

Tumor-related mutations in cell-free DNA in pre-operative plasma as a prognostic indicator of recurrence in endometrial cancer

D Shintani, T Hihara, A Ogasawara, S Sato… - International Journal of …, 2020 - ijgc.bmj.com
Objectives Circulating tumor DNA (ctDNA) has potential as a basis for understanding the
molecular features of a tumor non-invasively and for use as a diagnostic, prognostic, and …

Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists

K Kikuchi, K Tagami, S Hibi, H Yoshimura… - Bioorganic & medicinal …, 2001 - Elsevier
Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α
antagonists - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …

Syntheses and Structure− Activity Relationships of Novel Retinoid X Receptor Agonists

S Hibi, K Kikuchi, H Yoshimura, M Nagai… - Journal of medicinal …, 1998 - ACS Publications
As part of our studies to develop novel retinoids with increased affinity and selectivity for the
retinoid X receptor (RXR) subfamily, we have designed and synthesized a series of (E, E, E) …

Novel retinoic acid receptor α agonists: syntheses and evaluation of pyrazole derivatives

K Kikuchi, S Hibi, H Yoshimura, K Tai, T Hida… - Bioorganic & medicinal …, 2000 - Elsevier
We have designed and synthesized a series of pyrazole derivatives as candidate retinoic
acid receptor (RAR) agonists. One of them, 4-[5-(1, 5-diisopropyl-1H-3-pyrazolyl)-1H-2 …

Structure-Based Development of a Protein–Protein Interaction Inhibitor Targeting Tumor Necrosis Factor Receptor-Associated Factor 6

J Moriya, K Takeuchi, K Tai, K Arai… - Journal of medicinal …, 2015 - ACS Publications
The interactions between tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)
and TNF superfamily receptors (TNFRSFs) are promising targets for rheumatoid arthritis …

Mutagenesis of the fourth calcium-binding domain of yeast calmodulin

I Matsuura, E Kimura, K Tai, M Yazawa - Journal of Biological Chemistry, 1993 - ASBMB
The fourth calcium-binding domain (domain IV) of the yeast (Saccharomyces cerevisiae)
calmodulin is unable to bind Ca2+ (Matsuura, I., Ishihara, K., Nakai, Y., Yazawa, M., Toda …