Immunogenic apoptotic cell death and anticancer immunity

P Vandenabeele, K Vandecasteele, C Bachert… - Apoptosis in Cancer …, 2016 - Springer
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells
do not trigger an immune response but rather have anti-inflammatory properties. However …

Advanced ovarian cancer: primary or interval debulking? Five categories of patients in view of the results of randomized trials and tumor biology: primary debulking …

AP Makar, CG Tropé, P Tummers, H Denys… - The …, 2016 - academic.oup.com
Background. Standard treatment of stage III and IV advanced ovarian cancer (AOC) consists
of primary debulking surgery (PDS) followed by chemotherapy. Since the publication of the …

TILs in head and neck cancer: ready for clinical implementation and why (not)?

A De Meulenaere, T Vermassen, S Aspeslagh… - Head and neck …, 2017 - Springer
The assessment of tumor infiltrating lymphocytes (TILs) has recently emerged as a
prognostic biomarker in several solid tumors. Quantification and subtyping of TILs reflects …

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

J Tulkens, G Vergauwen, J Van Deun, E Geeurickx… - Gut, 2020 - gut.bmj.com
We read with interest recent papers reporting on the impact of gut microbiota on several
aspects of health and disease due to altered intestinal permeability resulting in systemic …

PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer

ASVM Van Den Heerik, N Horeweg, RA Nout… - International Journal of …, 2020 - ijgc.bmj.com
Background Vaginal brachytherapy is currently recommended as adjuvant treatment in
patients with high-intermediate risk endometrial cancer to maximize local control and has …

[HTML][HTML] Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

S Adjemian, T Oltean, S Martens, B Wiernicki… - Cell death & …, 2020 - nature.com
Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors.
Interestingly, few case reports underlined its potential to induce immune-mediated abscopal …

Development, external validation and clinical usefulness of a practical prediction model for radiation-induced dysphagia in lung cancer patients

C Dehing-Oberije, D De Ruysscher, S Petit… - Radiotherapy and …, 2010 - Elsevier
INTRODUCTION: Acute dysphagia is a distressing dose-limiting toxicity occurring frequently
during concurrent chemo-radiation or high-dose radiotherapy for lung cancer. It can lead to …

[HTML][HTML] REQUITE: a prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

P Seibold, A Webb, ME Aguado-Barrera, D Azria… - Radiotherapy and …, 2019 - Elsevier
Purpose REQUITE aimed to establish a resource for multi-national validation of models and
biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article …

[HTML][HTML] Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients

G Nalbantov, B Kietselaer, K Vandecasteele… - Radiotherapy and …, 2013 - Elsevier
Purpose To test the hypothesis that cardiac comorbidity before the start of radiotherapy (RT)
is associated with an increased risk of radiation-induced lung toxicity (RILT) in lung cancer …

[HTML][HTML] PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer

S Tuyaerts, AMT Van Nuffel, E Naert, PA Van Dam… - BMC cancer, 2019 - Springer
Background Immunotherapeutic approaches have revolutionized oncological practice but
are less evaluated in gynecological malignancies. PD-1/PD-L1 blockade in gynecological …