High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …

ContextAbout 2% of all colorectal cancer occurs in the context of the autosomal dominantly
inherited Lynch syndrome, which is due to mutations in mismatch repair genes. Potential risk …

Endometrial Cancer Endometrial carcinoma is diagnosed in about 58,500 women in the
United States per year. It is linked with obesity, excess estrogen, and the Lynch syndrome …

Background Women with the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
have a 40 to 60 percent lifetime risk of endometrial cancer and a 10 to 12 percent lifetime …

Importance Limited information about the relationship between specific mutations
inBRCA1orBRCA2 (BRCA1/2) and cancer risk exists. Objective To identify mutation-specific …

Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum.
However, the omental stromal cell-derived molecular determinants that modulate ovarian …

High-density array comparative genomic hybridization (CGH) showed amplification of
chromosome 1q22 centered on the RAB25 small GTPase, which is implicated in apical …

We demonstrate that phosphatidylinositol 3-kinase (PI3K) pathway aberrations occur in>
80% of endometrioid endometrial cancers, with coordinate mutations of multiple PI3K …

Purpose: Advanced-stage epithelial ovarian cancer has a poor prognosis with long-term
survival in less than 30% of patients. When the disease is detected in stage I, more than …

OBJECTIVE: Women with hereditary nonpolyposis colorectal cancer syndrome have a 40–
60% lifetime risk for colon cancer, a 40–60% lifetime risk for endometrial cancer, and a 12 …