User profiles for "author:K. Tryggvason"

Karl Tryggvason

Professor, Karolinska Institute, Stockholm & Duke-NUS, Singapore
Verified email at tryggvason.com
Cited by 60358

A simplified laminin nomenclature

…, K Sekiguchi, LM Sorokin, JF Talts, K Tryggvason… - Matrix biology, 2005 - Elsevier
A simplification of the laminin nomenclature is presented. Laminins are multidomain
heterotrimers composed of α, β and γ chains. Previously, laminin trimers were numbered …

Alport's syndrome, Goodpasture's syndrome, and type IV collagen

BG Hudson, K Tryggvason… - … England Journal of …, 2003 - Mass Medical Soc
Defects in type IV collagen, a collagenous protein involved in the formation of basement
membranes, have been implicated in hereditary Alport's syndrome and acquired …

Hereditary proteinuria syndromes and mechanisms of proteinuria

K Tryggvason, J Patrakka… - New England Journal of …, 2006 - Mass Medical Soc
Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria | NEJM Skip to main content
NEJM Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

LA Liotta, K Tryggvason, S Garbisa, I Hart, CM Foltz… - Nature, 1980 - nature.com
Tumour cells traverse epithelial and endothelial basement membranes during the
successive stages of the metastatic process. At the transition from in situ to invasive …

Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma

…, ML McGarvey, LA Liotta, PG Robey, K Tryggvason… - Biochemistry, 1982 - ACS Publications
Hynda K. Kleinman,** Mary L. McGarvey, Lance A. Liotta, Pamela Gehron Robey, Karl
Tryggvason, and George R. Martin abstract: We have studied the extractability of type IV …

[PDF][PDF] Positionally cloned gene for a novel glomerular protein—nephrin—is mutated in congenital nephrotic syndrome

…, L Peltonen, C Holmberg, A Olsen, K Tryggvason - Molecular cell, 1998 - cell.com
Congenital nephrotic syndrome of the Finnish type (NPHS1) is an autosomal-recessive
disorder, characterized by massive proteinuria in utero and nephrosis at birth. In this study …

Genomic instability in laminopathy-based premature aging

…, J Chen, Y Cao, KSE Cheah, K Tryggvason… - Nature medicine, 2005 - nature.com
Premature aging syndromes often result from mutations in nuclear proteins involved in the
maintenance of genomic integrity. Lamin A is a major component of the nuclear lamina and …

Mutations in the laminin α2–chain gene (LAMA2) cause merosin–deficient congenital muscular dystrophy

…, FMS Tomé, K Schwartz, M Fardeau, K Tryggvason… - Nature …, 1995 - nature.com
Congenital muscular dystrophies (CMDs), are heterogeneous autosomal recessive
disorders. Their severe manifestations consist of early hypotonia and weakness, markedly …

Identification of mutations in the COL4A5 collagen gene in Alport syndrome

…, MC Gregory, MH Skolnick, CL Atkin, K Tryggvason - Science, 1990 - science.org
X-linked Alport syndrome is a hereditary glomerulonephritis in which progressive loss of
kidney function is often accompanied by progressive loss of hearing. Ultrastructural defects …

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

…, KR Chien, J Inzunza, O Hovatta, K Tryggvason - Nature …, 2010 - nature.com
We describe a system for culturing human embryonic stem (hES) cells and induced
pluripotent stem (iPS) cells on a recombinant form of human laminin-511, a component of …